313963-77-8Relevant academic research and scientific papers
A green protocol for the one-pot multicomponent Petasis boronic Mannich reaction using ball milling
Hosseinzadeh,Lasemi,Oloub,Pooryousef
, p. 347 - 355 (2017)
Solvent-free reactions of salicylaldehyde with various boronic acids and amines were accomplished under ball-milling conditions to achieve the corresponding alkyl- and arylaminophenols in good to excellent yields. This simple protocol offers advantages su
Synthetic method of Betti base derivative
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Paragraph 0029, (2019/04/17)
The invention provides a synthetic method of a Betti base derivative. The Betti base derivative is prepared by: subjecting to 2-(hydroxy(phenyl)methyl)phenol compound and an amine compound to Sc(III)catalysis to generate an o-quinone methide, and carrying out nucleophilic addition; the product yield is 78-95%. The synthetic method is simple to perform; the materials and the reagents are simple; the reaction yield is high; the defects are avoided that a catalyst for the prior art is expensive and conditions for the prior art are strict; the product is easy to isolate and purify; the syntheticmethod is important to the synthesis of Betti base derivatives and has important value in the methodological study on o-quinone methides.
Ready N-alkylation of enantiopure aminophenols: Synthesis of tertiary aminophenols
Cimarelli, Cristina,Palmieri, Gianni,Volpini, Emanuela
, p. 6089 - 6096 (2007/10/03)
A regioselective indirect alkylation of aminophenols to enantiopure tertiary aminophenols, which are useful chiral ligands for metal-catalysed asymmetric reactions, is reported. This very simple synthetic methodology, through reduction or alkylation of an intermediate benzoxazine, was performed in mild conditions, suitable for the conservation of the configuration of the stereogenic centres. Some crystalline aminophenols show the phenomenon of 'crystallization-induced asymmetric transformation'.
