314035-77-3

Upstream product

• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 1371663-52-3 4-(2-hydroxy-5-methoxyphenyl)-6-(4-fluorophenyl)-2-aminopyrimidine 
• 312607-68-4 1-(4-fluorophenyl)-3-(2-hydroxy-5-methoxyphenyl)propane-1,3-dione 
• 313957-03-8 2-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one 

Relevant academic research and scientific papers

Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents

A novel series of 4,6-diaryl-2-aminopyrimidines 8a-o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61-9.53 μg/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.

Assessment of antiplatelet activity of 2-aminopyrimidines

A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds.