312607-68-4

Usage

Uses

Used in Food Industry:
Curcumin is used as a natural coloring agent for its bright yellow hue, adding visual appeal to various food products. It also serves as a flavoring agent, contributing to the taste and aroma of dishes.
Used in Dietary Supplements:
As a dietary supplement, Curcumin is consumed for its potential health benefits, which include anti-inflammatory, antioxidant, and anticancer properties.
Used in Traditional Medicine:
Curcumin has been a part of traditional medicine, where it is used to address various health conditions due to its purported therapeutic effects.
Used in Pharmaceutical Research:
Curcumin is a subject of pharmaceutical research for its potential in treating diseases such as cancer, arthritis, and neurodegenerative disorders. Its anti-inflammatory and antioxidant properties make it a promising candidate for further study and development in the medical field.

Upstream product

• 87428-52-2 2-hydroxy-3'-methoxyacetophenone 
• 403-43-0 4-fluorobenzoyl chloride 
• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 314035-77-3 C₁₆H₁₃FO₄ 

Downstream Products

• 313957-03-8 2-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one 
• 1371663-52-3 4-(2-hydroxy-5-methoxyphenyl)-6-(4-fluorophenyl)-2-aminopyrimidine 

Relevant academic research and scientific papers

Synthesis method of 2-aminopyrimidine antiplatelet compound

The invention discloses a synthesis method of a 2-aminopyrimidine antiplatelet compound, and the synthesis method comprises the following steps: selecting o-hydroxybenzaldehyde A and 2-bromoacetophenone B containing different substituent groups as raw materials, taking nitrogen heterocyclic carbene as a reaction catalyst, synthesizing an intermediate 1,3-diketone compound C of a novel antiplateletdrug under an alkaline condition, then synthesizing a flavonoid compound D under an acidic condition by the 1,3-diketone compound C, and finally generating the end product 2-aminopyrimidine antiplatelet compound E by the flavonoid compound D and guanidine hydrochloride under an alkaline condition. The synthesis method simplifies the original synthesis method from four steps to three steps, greatly simplifies the original synthesis method, thereby effectively reducing the production cost and the price of medicines, and improving the possibility for industrial production.

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase

The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.

Convenient one-pot synthesis of chromone derivatives and their antifungal and antibacterial evaluation

A one-pot method for the synthesis of chromone derivatives from the reaction of 2-hydroxyacetophenones with aliphatic or aromatic acid chlorides is reported. Esterification and Baker-Venkataraman rearrangement were promoted by t-BuOK, which was followed directly by acid-catalyzed cyclization in one pot. Some of 2-cyclohexyl- and 2-cyclohexylmethyl-substituted chromones displayed activity against plant pathogenic fungal strains. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents

A novel series of 4,6-diaryl-2-aminopyrimidines 8a-o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61-9.53 μg/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.

Assessment of antiplatelet activity of 2-aminopyrimidines

A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds.