314046-82-7Relevant academic research and scientific papers
Enantioselective N-Acylation of Biginelli Dihydropyrimidines by Oxidative NHC Catalysis
Brandolese, Arianna,Ragno, Daniele,Leonardi, Costanza,Di Carmine, Graziano,Bortolini, Olga,De Risi, Carmela,Massi, Alessandro
, p. 2439 - 2447 (2020/04/30)
The oxidative N-acylation reaction of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) with enals and N-heterocyclic carbene (NHC) catalysts is described. The reaction proceeds in the presence of quinone oxidant without additional acyl transfer agents and in the
A convenient one-pot Biginelli reaction catalyzed by Y(OAc)3: An improved protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and their sulfur analogues
Aridoss, Gopalakrishnan,Jeong, Yeon Tae
experimental part, p. 863 - 868 (2010/10/19)
Yttrium(III) acetate hydrate-catalyzed novel synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one derivatives was achieved through one-pot three-component condensation of diversified aldehydes, β-ketoesters and urea or N-methylurea or thiourea with a molar r
Pharmacologically relevant bifunctional compounds containing chloroquinoline and dihydropyrimidone moieties: Syntheses and crystal structures of a target molecule and selected intermediates
Watermeyer, Nicholas D.,Chibale, Kelly,Caira, Mino R.
experimental part, p. 753 - 760 (2010/06/19)
We report the regioselective synthesis and X-ray structure of the pharmacologically relevant 3-[2-(7-chloro-quinolin-4-ylamino)-ethylcarbamoyl]-4- (4-methoxy-phenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5- carboxylic acid methyl ester (3) (tri
