314080-71-2

Upstream product

• 314080-69-8 Toluene-4-sulfonic acid (1R,3R,4R,7S)-7-hydroxy-3-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester 
• 314080-68-7 C₃₂H₃₄N₂O₁₂S₂ 
• 314080-67-6 C₃₅H₃₈N₂O₁₂S₂ 
• 314080-66-5 C₂₇H₃₀N₂O₁₁S₂ 

Downstream Products

• 293751-31-2 Benzoic acid (1R,3R,4R,7S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7-hydroxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester 
• 206055-76-7 5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite 
• 195705-32-9 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methyleneuridine 
• 200435-92-3 1-((1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidine-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

DNA triplex structures are stabilized by the incorporation of 3'-endo blocked pyrimidine nucleosides in the hoogsteen strand

A short route to pyrimidine locked nucleosides has been developed for their incorporation in triplex forming oligonucleotides (TFO). Compared to oligonucleotides built with standard nucleosides, the modified TFOs containing 3'-endo blocked residues formed