293751-31-2

Upstream product

• 532-32-1 sodium benzoate 
• 314080-71-2 Toluene-4-sulfonic acid (1R,3R,4R,7S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7-hydroxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester 
• 293751-29-8 C₃₀H₂₆N₂O₇ 
• 314080-68-7 C₃₂H₃₄N₂O₁₂S₂ 
• 314080-67-6 C₃₅H₃₈N₂O₁₂S₂ 
• 314080-66-5 C₂₇H₃₀N₂O₁₁S₂ 
• 314080-69-8 Toluene-4-sulfonic acid (1R,3R,4R,7S)-7-hydroxy-3-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester 

Downstream Products

• 195705-32-9 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methyleneuridine 
• 200435-92-3 1-((1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidine-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

IMPROVED SYNTHESIS OF ?2.2.1|BICYCLO NUCLEOSIDES

A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. F

DNA triplex structures are stabilized by the incorporation of 3'-endo blocked pyrimidine nucleosides in the hoogsteen strand

A short route to pyrimidine locked nucleosides has been developed for their incorporation in triplex forming oligonucleotides (TFO). Compared to oligonucleotides built with standard nucleosides, the modified TFOs containing 3'-endo blocked residues formed