31419-26-8

Basic information

• Product Name: n-butyl 2-(carbomethoxy)phenyl sulfoxide
• Synonyms: n-butyl 2-(carbomethoxy)phenyl sulfoxide
• CAS NO: 31419-26-8
• Molecular Weight: 240.323
• Mol File: 31419-26-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: n-butyl 2-(carbomethoxy)phenyl sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: n-butyl 2-(carbomethoxy)phenyl sulfoxide(31419-26-8)
• EPA Substance Registry System: n-butyl 2-(carbomethoxy)phenyl sulfoxide(31419-26-8)

Safety Data

• Hazardous Substances Data: 31419-26-8(Hazardous Substances Data)

Upstream product

• 147-93-3 Thiosalicylic acid 
• 17839-61-1 (S-butyl)-2-thiosalicylic acid 
• 100789-98-8 n-butyl 2-(carbomethoxy)phenyl sulfide 
• 186581-53-3 diazomethane 
• 154017-82-0 2-(Butane-1-sulfinyl)-benzoic acid 

Downstream Products

• 5459-63-2 bis[2-(methoxycarbonyl)phenyl]disulfide 
• 4016-59-5 2-(methoxycarbonyl)phenyl 2-(methoxycarbonyl)benzenethiosulfonate 
• 100790-15-6 methyl trans-3-<(2-(methoxycarbonyl)phenyl)sulfinyl>acrylate 

Relevant articles and documents

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.

Chemistry of Sulfenic Acids. 7. Reason for the High Reactivity of Sulfenic Acids. Stabilization by Intramolecular Hydrogen Bonding and Electronegativity Effects

It is proposed that the reason sulfenic acids (RSOH) are so reactive and usually not isolated or even detected is that they form thiosulfinates (RS(O)SR) so readily.This is a consequence of the sulfenic acid hydrogen-bonded dimer, 1, which lowers the energy of activation for thiosulfinate formation.The stability of the few sulfenic acids that have been isolated can be explained in terms of steric, electronic, and intramolecular hydrogen-bonding effects which prevent dimer formation.The importance of these effects on the stability of simple unstable sulfenic acids was demonstrated by flash vacuum pyrolysis (FVP) and the thiosulfinate/vinyl sulfoxide ratio.A novel, high yield, rearrangement of sulfenic acid 19f to 1,3-benzothiazine 26 was observed.