17839-61-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(Butylthio)benzoic acid is utilized as a building block for the synthesis of various pharmaceuticals. Its structural characteristics make it a valuable component in the development of anti-inflammatory, anti-fungal, and anti-bacterial agents, contributing to the creation of new medications with improved therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Butylthio)benzoic acid serves as a key intermediate in the synthesis of compounds with pesticidal properties. Its incorporation into agrochemical products can enhance their effectiveness in controlling pests and diseases in agriculture, thereby increasing crop yields and quality.
Used in Organic Chemistry Research:
2-(Butylthio)benzoic acid is employed as a reagent in organic chemistry reactions. It is instrumental in the synthesis of new compounds with desired properties, such as improved stability, reactivity, or selectivity. This makes it a valuable tool for researchers in the field of organic chemistry, enabling the exploration of novel chemical pathways and the discovery of innovative molecules.

Upstream product

• 109-65-9 1-bromo-butane 
• 147-93-3 Thiosalicylic acid 
• 100789-98-8 n-butyl 2-(carbomethoxy)phenyl sulfide 
• 4892-02-8 Methyl thiosalicylate 
• 542-69-8 1-iodo-butane 
• 7283-41-2 thiosalicilyc acid 
• 140-89-6 potassium ethyl xanthogenate 
• 118-92-3 anthranilic acid 
• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 1126-80-3 (n-butylthio)benzene 

Downstream Products

• 154017-82-0 2-(Butane-1-sulfinyl)-benzoic acid 
• 37527-70-1 2-(n-butylthio)benzyl alcohol 
• 31419-26-8 n-butyl 2-(carbomethoxy)phenyl sulfoxide 
• 67032-53-5 2-butylmercapto-benzoic acid-(2-piperidino-ethyl ester) 
• 67032-50-2 2-butylsulfanyl-benzoic acid-(2-diethylamino-ethyl ester) 
• 67032-52-4 2-butylsulfanyl-benzoic acid-(3-diethylamino-propyl ester) 
• 1242951-54-7 (2-butylthiobenzoyl)ferrocene 
• 6629-33-0 3-Propyl-4-thiaisochromanon-(1) 
• 57076-15-0 2-butylsulfonylbenzoic acid 
• 37527-75-6 (2-Butylsulfanyl-phenyl)-acetic acid 
• 37527-73-4 2-(2-(butylthio)phenyl)acetonitrile 
• 37527-71-2 2-Butylthiobenzylchlorid 
• 37527-77-8 (2-butylsulfanyl-phenyl)-acetic acid methyl ester 
• 37527-81-4 [2-(Butane-1-sulfinyl)-phenyl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.

DNA binding and antitumor activities of platinum(IV) and zinc(II) complexes with some S-alkyl derivatives of thiosalicylic acid

A series of complexes of platinum(IV) (C1–C5) and zinc(II) (C6–C10) with S-alkyl derivatives of thiosalicylic acid were prepared and characterized. The interactions of the complexes with calf thymus DNA were analyzed by absorption (UV–Vis) and emission spectral studies (ethidium bromide displacement studies). The cytotoxic activities of complexes C1–C10 were determined against mouse B cell lymphocytic leukemia cells (BCL1), human B-prolymphocytic leukemia (JVM-13), mouse mammary carcinoma cells (4T1), and human mammary carcinoma cells (MDA-MB-468) and compared to the activities of the free ligand precursors and cisplatin. The cytotoxicities of the platinum(IV) and zinc(II) complexes toward mouse tumor cell lines were higher compared with their effects on human tumor cell lines. The zinc(II) complex C9 showed the highest antitumor activity toward the tested human cell lines, while the platinum(IV) complex C4 exhibited the highest antitumor activity toward mouse BCL1 and 4T1 cells. Both C4 and C9 have ligands derived from S-propyl thiosalicylic acid.

Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid

The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl deriva

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis

Palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) are endogenous lipid mediators that suppress inflammation. Their actions are terminated by the intracellular cysteine amidase, N-acylethanolamine acid amidase (NAAA). Even though NAAA may offer a new target for anti-inflammatory therapy, the lipid-like structures and reactive warheads of current NAAA inhibitors limit the use of these agents as oral drugs. A series of novel benzothiazole–piperazine derivatives that inhibit NAAA in a potent and selective manner by a non-covalent mechanism are described. A prototype member of this class (8) displays high oral bioavailability, access to the central nervous system (CNS), and strong activity in a mouse model of multiple sclerosis (MS). This compound exemplifies a second generation of non-covalent NAAA inhibitors that may be useful in the treatment of MS and other chronic CNS disorders.

Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2]

The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)2] consists of neutr

Synthesis, characterization and antimicrobial activity of copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II) complex with S-methyl derivative of thiosalicylic acid

The five new copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid (alkyl = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4), butyl (L5)) have been synthesized and characterized by microanalysis and infrared spectra. The spectroscopica

Synthesis, spectral characterization and electrochemical properties of (2-alkylthiobenzoyl)ferrocenes. Crystal structures of 2-methylthio, 2-ethylthio and 2-isopropylthio derivatives

The one-pot synthesis of seven new (2-alkylthiobenzoyl)ferrocenes has been achieved by Friedel-Crafts acylation of ferrocene with acid chlorides generated in situ from the corresponding carboxylic acids and phosphorous trichloride. The obtained compounds

Lipase-catalyzed kinetic resolution of a series of esters having a sulfoxide group as the stereogenic centre

A series of methyl 2-(alkylsulfinyl)benzoates (alkyl = C1, n-C4, n-C8, n-C12 and n-C16) was investigated with respect to substrate behaviour and enantioselectivity in a lipase (Candida rugosa)-catalyz

DIHYDROPYRIMIDINE LACTONE DERIVATIVES

Novel compounds of the formula STR1 wherein X is sulfur or oxygen, R 2 is aryl or heterocyclo and R 1 is as defined herein, are disclosed. Compounds of formula I possess calcium channel activating activity.