17839-61-1Relevant articles and documents
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold
Rotondi, Giulia,Guglielmi, Paolo,Carradori, Simone,Secci, Daniela,De Monte, Celeste,De Filippis, Barbara,Maccallini, Cristina,Amoroso, Rosa,Cirilli, Roberto,Akdemir, Atilla,Angeli, Andrea,Supuran, Claudiu T.
, p. 1400 - 1413 (2019/08/26)
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.
Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid
Nikoli?, Milo? V.,Mijajlovi?, Marina ?.,Jevti?, Verica V.,Ratkovi?, Zoran R.,Novakovi?, Sladjana B.,Bogdanovi?, Goran A.,Milovanovi?, Jelena,Arsenijevi?, Aleksandar,Stojanovi?, Bojana,Trifunovi?, Sre?ko R.,Radi?, Gordana P.
, p. 264 - 271 (2016/04/04)
The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl deriva
Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2]
Mijajlovi?, Marina ?.,Nikoli?, Milo? V.,Jevti?, Verica V.,Ratkovi?, Zoran R.,Markovi?, Bojana Simovi?,Volarevi?, Vladislav,Arsenijevi?, Neboj?a N.,Novakovi?, Sladjana B.,Bogdanovi?, Goran A.,Trifunovi?, Sre?ko R.,Radi?, Gordana P.
, p. 34 - 40 (2015/03/04)
The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)2] consists of neutr