31419-64-4

Upstream product

• 119770-51-3 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)pentan-2-one 
• 119770-40-0 5-(p-carbomethoxyphenyl)-1-phthalimido-3-penten-2-one 
• 1571-08-0 methyl 4-formylbenzoate 
• 106918-32-5 4-carbomethoxyphenylacetaldehyde 
• 119770-43-3 5-(p-carbomethoxyphenyl)-1-phthalimidopentan-2-one 
• 119770-39-7 5-(p-carbomethoxyphenyl)-1-phthalimido-4-penten-2-one 
• 119770-41-1 5-(p-carbomethoxyphenyl)-2-hydroxy-1-phthalimidopentane 
• 106918-31-4 1-methoxy-2-(4-carbomethoxyphenyl)ethylene 
• 119770-49-9 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime 
• 119770-45-5 5-(p-carbomethoxyphenyl)-1-phthalimidopentan-2-one oxime 

Downstream Products

• 119770-58-0 (6S)-11-deazatetrahydrohomofolate 
• 119770-56-8 11-deaza-7,8-dihydrohomofolate 
• 119770-54-6 11-deazahomofolic acid 

Relevant academic research and scientific papers

Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase

The Boon-Leigh procedure, involving condensation of a 6-chloro-5-nitropyrimidine (22) with an α-amino ketone (20 or 21) followed by reduction of the nitro group, cyclization, and L-glutamylation, led to the formation of 11-deazahomofolate (29) and its 10-