314251-04-2Relevant academic research and scientific papers
Discovery and potency optimization of 2-amino-5-arylmethyl-1,3-thiazole derivatives as potential therapeutic agents for prostate cancer
Krasavin, Mikhail,Karapetian, Ruben,Konstantinov, Igor,Gezentsvey, Yuri,Bukhryakov, Konstantin,Godovykh, Elena,Soldatkina, Olga,Lavrovsky, Yan,Sosnov, Andrei V.,Gakh, Andrei A.
experimental part, p. 420 - 427 (2009/11/30)
A new chemical series was identified via high-throughput screening as having antiproliferative activity on DU-145 human prostate carcinoma cell line (hit compound potency - 2.9 μM). Medicinal chemistry optimization of two peripheral diversity vectors of t
