314264-83-0Relevant academic research and scientific papers
Enzymic resolution of an α-methylene-γ-lactonic ester
Pitacco, Giuliana,O Santi, Andrea Sessanta,Valentin, Ennio
, p. 3263 - 3267 (2000)
The possibility of using enzymes for the kinetic resolution of an α-methylene-γ-lactone was explored. The probe molecule, ethyl 2-methyl-4-methylene-tetrahydro-5-oxo-2-furancarboxylate was successfully resolved with Porcine pancreatic lipase and Candida rugosa lipase, in the presence of a cosolvent, leading to both enantiomers of the corresponding acid with high enantiomeric excesses. Copyright (C) 2000 Elsevier Science Ltd.
