31430-19-0

Basic information

• Product Name: Mebendazole Ethyl Ester
• Synonyms: Mebendazole Ethyl Ester;(5-Benzoyl-1H-benziMidazol-2-yl)carbaMic Acid Ethyl Ester;5-Benzoyl-2-benziMidazolecarbaMic Acid Ethyl Ester;N-(6-Benzoyl-1H-benziMidazol-2-yl)carbaMic Acid Ethyl Ester;Mebendazole IMpurity E;Mebendazole Ethyl Analog;Mebendazole Related CoMpound E;Mebendazole EP impurity E
• CAS NO: 31430-19-0
• Molecular Formula: C₁₇H₁₅N₃O₃
• Molecular Weight: 308.31136
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 31430-19-0.mol

Chemical Properties

• Appearance: /
• Density: 1.349±0.06 g/cm3(Predicted)
• Storage Temp.: Amber Vial, Refrigerator
• Solubility: DMSO (Slightly, Heated)
• PKA: 9.97±0.10(Predicted)
• CAS DataBase Reference: Mebendazole Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Mebendazole Ethyl Ester(31430-19-0)
• EPA Substance Registry System: Mebendazole Ethyl Ester(31430-19-0)

Safety Data

• Hazardous Substances Data: 31430-19-0(Hazardous Substances Data)

Usage

Uses

Mebendazole (M200500) metabolite.

Upstream product

• 1320358-37-9 C₁₇H₁₇N₃O₃S 

Relevant articles and documents

Phosphonium-mediated cyclization of N-(2-aminophenyl)thioureas: Efficient synthesis of 2-aminobenzimidazoles

BOP efficiently promoted the phosphonium-mediated cyclization of thioureas, leading to a convenient synthesis of 2-aminobenzimidazoles. Compared to conventional methods, the reactions were complete at room temperature with times ranging from a few minutes

Synthesis and anthelminthic acitivity of alkyl-(5-acyl-1-benzimidazol-2-yl) carbamates

A series of alkyl-(5-acyl-l-H-benzimidazol-2-yl)-carbamates were prepared and screened for anthelminthic activity. Some of them were found to be fully active at low, atoxic oral dose levels against gastro-intestinal nematodes. The activity against Syphacia muris and Strongyloides ratta is indicated. From these studies methyl (5-benzoyl-1-H-benzimidazol-2-yl) carbamate (mebendazole) and methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl]carbamate (flubendazole) were selected for detailed investigation.