3144-11-4

Usage

Sulfonamide derivative

contains a sulfonamide group (-SO2NH2)
The compound has a specific functional group consisting of a sulfur atom double-bonded to an oxygen atom and single-bonded to a nitrogen atom, which is connected to two hydrogen atoms.

Hexane chain attachment

to the sulfonamide group
The hexane chain, which is a straight-chain alkane with six carbon atoms, is attached to the sulfonamide group, forming the structure of 1-Hexanesulfonamide.

Primary use

as a plasticizer
1-Hexanesulfonamide is used to reduce the viscosity of polymers, making them more flexible and easier to process.

Secondary use

as an intermediate in chemical production
The compound serves as a starting material or building block in the synthesis of other chemicals.

Applications

in adhesives, coatings, and sealants
1-Hexanesulfonamide is utilized in the production of various industrial products, such as adhesives, coatings, and sealants, due to its ability to modify the properties of polymers.

Precursor in synthesis

pharmaceuticals and agrochemicals
The compound can act as a precursor in the synthesis of pharmaceuticals and agrochemicals, which are chemicals used in the medical and agricultural industries, respectively.

Low toxicity

generally considered to be of low toxicity
1-Hexanesulfonamide is not highly toxic; however, proper handling and disposal procedures should be followed to minimize potential environmental and health hazards.

Upstream product

• 111-25-1 1-bromo-hexane 
• 6803-40-3 1-hexylthiocyanate 
• 14532-24-2 1-hexanesulfonyl chloride 

Downstream Products

• 926299-63-0 3-[1-(2,4-dichlorobenzyl)-3-isopropoxy-1H-pyrazol-5-yl]-N-(hexylsulfonyl)propanamide 
• 1621673-53-7 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide 
• 95805-83-7 Trianilinophosphazosulfonylhexyl 
• 101957-73-7 N--hexan-sulfonimidsaeure-(1)-<4-nitro-phenylester> 
• 95953-92-7 Tris-<4-nitro-phenoxy>-phosphazosulfonylhexyl 
• 139669-08-2 N-[[(4-chlorophenyl)amino]carbonyl]-1-hexanesulfonamide 

Relevant academic research and scientific papers

Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

Series of perfluoroalkanesulfonamides 1, sodium salt of perfluoroalkanesulfonamides 2 and polyfluoroalkanesulfonamides 3 derivatives were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR, IR and HRMS. Inhibition effects of these compounds on bovine carbonic anhydrase (bCA) and human carbonic anhydrase isoenzyme II (hCA) have been investigated. Comparing IC50 values of the synthesized molecules 1, 2 and 3, it has been found that compound 2b is a more potent inhibitor than acetazolamide on hCA. Moreover 2b does not present cellular toxicity on sheep red globules.

Pharmaceutical Compositions Based on Fluorinated Sulphamides and Sulphinimides

Pharmacuetical composition comprising compounds of formula (I): [in-line-formulae]NZ1Z2Z3 ??(I) [/in-line-formulae] in which: Z1, Z2, Z3 each independently of the others represents: a hydrogen atom; C1-C6-alkyl group; a group —SO2R3 wherein R3 represents a linear or branched C1-C12-alkyl, -alkenyl or -alkynyl group, a C3-C10-cycloalkyl group or a C6-C10-aryl group, a (C1-C6)-alkyl-(C6-C14)-aryl group, or a C5-C10-heteroaryl group; it being understood that at least one of the groups Z1, Z2, Z3 represents a group of formula (II) [in-line-formulae]X—RF—(CH2)n—SO2—??(II) [/in-line-formulae] X, RF and n being as defined in claim 1.

Intramolecular asymmetric amidations of sulfonamides and sulfamates catalyzed by chiral dirhodium(II) complexes

Enantioselective intramolecular amidation of aliphatic sulfonamides was achieved for the first time by means of chiral carboxylatodirhodium(II) catalysts in conjunction with PhI(OAc)2 and MgO in high yields and with enantioselectivities of up to 66% (Scheme 3, Table 1). The best results were obtained with [Rh2{(S)-nttI)4] and [Rh 2{(R)-ntv)4] as catalysts ((S)-nttl = (αS)-α- (tert-butyl)-1,3-dioxo-2H-benz[de]isoquinoline-2-acetato, (R)-nto = (αR)-α-isopropyl-1,3-dioxo-2H-benz[de] isoquinoline-2-acetato). In addition, these carboxylatodirhodium(II) catalysts were also efficient in intramolecular amidations of aliphatic sulfamates esters, although the enantioselectivity of these latter reactions was significantly lower (Scheme 4, Table 3).

5(Z)-7-(endo-3-benzenesulfonamidobicyclo[2.2.1]hept-exo-2-yl)-5-heptenoic acid, sodium salt

There is provided 5(Z)-7-(endo-3-benzenesulfonamidobicyclo[2.2.1]hept-exo-2-yl)-5-heptenoic acid, sodium salt which is useful as an antithrombotic, anti-vasoconstricting and anti-bronchoconstricting agent.

Bicyclic sulfonamide derivatives

Bicyclic sulfonamido derivatives represented by the formula: STR1 wherein R1 is a hydrogen or lower alkyl; R2 is an alkyl, substituted or unsubstituted aryl, aralkyl or heterocycle; R3 is a hydrogen or methyl; X is an alky