31444-18-5Relevant academic research and scientific papers
PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RELIEVING PAIN AND TREATING CENTRAL NERVOUS SYSTEM DISORDERS
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Page/Page column 80, (2008/06/13)
Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas (1 or 2), as described herein. The compounds of Formulas (1 and 2) are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.
New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist
Conti, Paola,Kozikowski, Alan P.
, p. 4053 - 4056 (2007/10/03)
A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.
6-Substituted Bicyclohept-5-en-2-one Ketals
Lal, Kasturi,Salomon, Robert G.
, p. 2628 - 2632 (2007/10/02)
Structurally specific syntheses of isomerically pure 6-substituted bicyclohept-5-en-2-one ketals were explored.A conversion of the Diels-Alder adduct of itaconic anhydride with cyclopenta-1,3-diene into a ketal of 6-methylbicyclohept-5-en-2-one was accomplished, but the last step, an oxidative vicinal bisdecarboxylation, gave only a 35percent yield.The ethylene ketal of 6-methylbicyclohept-5-en-2-one was prepared in 80percent overall yield from bicyclohept-5-en-2-one by a regioselective replacement of hydrogen with a methyl group.Practical synthesesof the 6-bromo, 6-carbomethoxy, 6-phenylthio, and 6-trimethylsilyl analogues were accomplished similarly.
Deamination Reactions, 48. - Decomposition of 5- and 6-Alkoxy-2-norbornanediazonium Ions
Kirmse, Wolfgang,Siegfried, Rainer,Feldmann, Georg,Schoen, Sabine,Schwarz, Johannes
, p. 477 - 484 (2007/10/02)
The aim of the present investigation was to probe the effect of 5- and 6-alkoxy substituents on the Wagner-Meerwein rearrangement of 2-norbornyl cations.The cations were generated by decomposition of the analogous diazonium ions since 6-methoxy-2-norbornyl tosylates are known to react with complete fragmentation.With the exception of 38, all 6-alkoxy-2-norbornane-diazonium ions gave acceptable yields of exo alcohols in addition to fragmentation products.These exo alcohols were formed without Wagner-Meerwein rearrangement, as indicated by the distribution of isomers or deuterium labels. 6,6-Dimethoxy-2-norbornanediazonium ions (27) showed an additional endo-6,2-OCH3 shift which was not observed with the endo-6-methoxy species 20b.In contrast, the Wagner-Meerwein rearrangement was virtually unaffected by 5-alkoxy substituents.We assume that alkoxy groups at C-6 destabilize the bridged structure of 2-norbornyl cations, as suggested by ab-inito calculations on protonated cyclopropanes.
Synthesis, stereochemistry, and transformations of (E)-1,2-bis(benzenesulfonyl)ethylene cycloadducts to 2-oxa substituted 1,3-dienes
Lucchi, Ottorino De,Lucchini, Vittorio,Zamai, Moreno,Modena, Giorgio,Valle, Giovanni
, p. 2487 - 2497 (2007/10/02)
The cycloaddition of (E)-1,2-bis(benzenesulfonyl)ethylene (2) to 2-acetoxy- and 2-silyloxy-1,3-cyclodienes occurs in high yields and with high stereoselectivity.Structure assignment has been based largely on 1H nmr nuclear Overhauser effect (nOe) experime
