314753-72-5Relevant academic research and scientific papers
Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives
Murty,Ram, Kesur R.,Rao, B. Ramalingeswara,Rao, Rayudu Venkateswara,Katiki, Mohana Rao,Rao, Janapala Venkateswara,Pamanji,Velatooru
, p. 1661 - 1671 (2014/05/06)
A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.
LIQUID-CRYSTALLINE IMIDAZO-1,3,4-THIADIAZOLES. I. SYNTHESIS OF 2,6-DISUBSTITUTED IMIDAZO-1,3,4-THIADIAZOLES AND THEIR MESOMORPHOUS AND SPECTRAL CHARACTERISTICS
Torgova, S. I.,Abolin, A. G.,Karamysheva, L. A.,Ivashchenko, A. V.
, p. 172 - 178 (2007/10/02)
Derivatives of imidazo-1,3,4-thiadiazole possessing a wide temperature range of smectic mesophase were obtained.The introduction of the cyclohexane fragment into the imidazole part of the molecule promotes the appearance of the nematic mesophase.The structure of the new mesogens and of the intermediates in their synthesis were confirmed by the data from IR and (13)C and (1)H NMR spectroscopy.
