314753-72-5

Upstream product

• 28788-62-7 4-butylbenzoyl chloride 
• 79-19-6 thiosemicarbazide 
• 333-20-0 potassium thioacyanate 
• 20651-71-2 4-butyl benzoic acid 
• 20651-69-8 methyl 4-(n-butyl)benzoate 

Downstream Products

• 114751-64-3 2-(4-Butyl-phenyl)-6-(4-pentyl-phenyl)-imidazo[2,1-b][1,3,4]thiadiazole 
• 114751-66-5 6-(4-Butyl-cyclohexyl)-2-(4-butyl-phenyl)-imidazo[2,1-b][1,3,4]thiadiazole 
• 114751-67-6 2-(4-Butyl-phenyl)-6-[4-(4-propyl-cyclohexyl)-phenyl]-imidazo[2,1-b][1,3,4]thiadiazole 
• 114751-55-2 4-[2-(4-Butyl-phenyl)-imidazo[2,1-b][1,3,4]thiadiazol-6-yl]-benzonitrile 
• 1499949-66-4 C₁₂H₁₅N₃S 

Relevant academic research and scientific papers

Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.

LIQUID-CRYSTALLINE IMIDAZO-1,3,4-THIADIAZOLES. I. SYNTHESIS OF 2,6-DISUBSTITUTED IMIDAZO-1,3,4-THIADIAZOLES AND THEIR MESOMORPHOUS AND SPECTRAL CHARACTERISTICS

Derivatives of imidazo-1,3,4-thiadiazole possessing a wide temperature range of smectic mesophase were obtained.The introduction of the cyclohexane fragment into the imidazole part of the molecule promotes the appearance of the nematic mesophase.The structure of the new mesogens and of the intermediates in their synthesis were confirmed by the data from IR and (13)C and (1)H NMR spectroscopy.