314769-68-1Relevant academic research and scientific papers
Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium(II), rhodium(III) and iridium(III) complexes of 2-phenylbenzimidazoles
Rylands, Laa-iqa,Welsh, Athi,Maepa, Keletso,Stringer, Tameryn,Taylor, Dale,Chibale, Kelly,Smith, Gregory S.
, p. 11 - 21 (2019)
Benzimidazoles, such as albendazole, thiabendazole and omeprazole have antiplasmodial activity against Plasmodium falciparum and are widely used as scaffolds for metal-based drug research. Incorporating substituents with various lipophilic and electronic
Catalytic Oxidative Coupling of Primary Amines under Air: A Flexible Route to Benzimidazole Derivatives
Nguyen, Khac Minh Huy,Largeron, Martine
, p. 1025 - 1032 (2016/03/01)
Benzimidazoles are of fundamental importance in chemistry and biology, and the development of efficient, environmentally benign methods for their preparation remains a key challenge for organic chemists. In a biomimetic approach inspired by copper amine oxidases, we disclose herein the scope and factors influencing the success of the cooperative action of CuBr2 as electron-transfer mediator and a topaquinone-like substrate-selective catalyst in the oxidative cyclocondensation of primary amines with o-aminoanilines. This one-pot atom-economic multistep process, which works under green conditions with ambient air as the terminal oxidant, low loadings of catalyst, and equimolar amounts of commercially available amine substrates, is particularly suitable for the preparation of 1,2-disubstituted benzimidazoles. Furthermore, it allows the functionalization of nonactivated primary aliphatic amines, which are known to be challenging substrates for non-enzymatic catalytic aerobic systems.
One-pot synthesis of imidazole derivatives under solvent-free condition
Zhang, Qiu-Gen,Xie, Yu,Hu, Jin-Gang,Liu, Jin-Mei,Wang, Juan,Zhong, Rong,Gao, Yun-Hua
scheme or table, p. 4611 - 4613 (2012/08/28)
A convenient and environment-friendly solvent-free procedure has been developed for one-pot synthesis of imidazole derivatives. On comparing the new method with the classical reaction condition, this new synthetic method shows many advantages such as high
