31502-87-1

Basic information

• Product Name: 1,4-Bis(7-chloroquinolin-4-yl)piperazine
• Synonyms: 1,4-Bis(7-chloroquinolin-4-yl)piperazine;4,4'-(1,4-Piperazinediyl)bis[7-chloroquinoline]
• CAS NO: 31502-87-1
• Molecular Formula: C22H18Cl2N4
• Molecular Weight: 409.31112
• Mol File: 31502-87-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 241℃
• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: DMSO (Very Slightly, Heated)
• CAS DataBase Reference: 1,4-Bis(7-chloroquinolin-4-yl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Bis(7-chloroquinolin-4-yl)piperazine(31502-87-1)
• EPA Substance Registry System: 1,4-Bis(7-chloroquinolin-4-yl)piperazine(31502-87-1)

Safety Data

• Hazardous Substances Data: 31502-87-1(Hazardous Substances Data)

Usage

Uses

1,4-bis(7-Chloroquinolin-4-yl)piperazine, is a derivative of aminoquinolines, that have been shown to have antiparasitic, antimicrobial and antifungal activities.

Upstream product

• 110-85-0 piperazine 
• 86-98-6 4,7-dichloroquinoline 

Relevant articles and documents

Synthesis and characterization of impurities present in an antimalarial drug piperaquine phosphate

Six impurities formed during the process development of piperaquine phosphate, were identified as 7-chloro-4-(piperazine-1-yl) quinoline A, 3-(4-(7-chloroquinolin-4-yl) piperazine-1-yl) propan-1-ol B, 7-chloro-4-(4-(3-ethoxypropyl) piperazine-1-yl) quinoline C, 1,4-bis (7-chloro-4-quinolinyl) piperazine D, 7-chloro-4-(4-{3- [(7-chloro quinolin-4-yl) oxy] propyl} piperazine-1-yl) quinoline E and 4,4'-[piperazine-1,4-diyl] bis (propane-3,1-diylpiperazine - 4,1-diyl)] bis (7-chloroquinoline) F by LC-MS. The structures of these impurities were further confirmed by synthesis. HPLC analysis of piperaquine phosphate API showed impurities ranging from 0.05 to 0.22%.