31522-01-7Relevant academic research and scientific papers
Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain
Iyer, Divyaanka,Vartak, Supriya V.,Srivastava, Mrinal,Hegde, Mahesh,Gopalakrishnan, Vidya,Raghavan, Sathees C.,Mishra, Archita,Surolia, Avadhesha,Goldsmith, Gunaseelan,Velusamy, Mahesh,Choudhary, Bibha,Kumar, Sujeet,Karki, Subhas S.,Glenn, Mark,Kalakonda, Nagesh
, p. 3408 - 3437 (2016/12/31)
The antiapoptotic protein BCL2 is overexpressed in several cancers and contributes to prolonged cell survival and chemoresistance, lending itself as an excellent target for cancer therapy. Here, we report the design, synthesis, and characterization of Dis
Synthesis and cardiotonic activity of certain imidazo[2,1-b]-1,3,4-thiadiazole derivatives
El-Sherbeny,El-Bendary,El-Subbagh,El-Kashef
, p. 253 - 256 (2007/10/03)
A series of 5-imino-2-methyl-4-(4'-substituted phenacyl)-1,3,4-thiadiazole derivatives 3-5 have been synthesized and furtherly used to prepare a series of 2-methyl-6-(4'-substituted phenyl)imidazo[2,1-b]-1,3,4-thiadiazoles 6-8 and 5-substituted-2-methyl-6
