315224-26-1 Usage
General Description
INT-131, also known as Pargluva, is a chemical compound that was developed as a potential treatment for type 2 diabetes. It works by targeting the PPAR-alpha and PPAR-gamma receptors, which are involved in the regulation of glucose and lipid metabolism. INT-131 has been shown to improve insulin sensitivity and lower blood sugar levels in diabetic patients, making it a promising candidate for the treatment of this condition. However, clinical trials have shown some safety concerns, including an increased risk of heart failure, and as a result, further development of INT-131 as a diabetes treatment has been discontinued.
Check Digit Verification of cas no
The CAS Registry Mumber 315224-26-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,5,2,2 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 315224-26:
(8*3)+(7*1)+(6*5)+(5*2)+(4*2)+(3*4)+(2*2)+(1*6)=101
101 % 10 = 1
So 315224-26-1 is a valid CAS Registry Number.
315224-26-1Relevant articles and documents
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics
Frkic, Rebecca L.,He, Yuanjun,Rodriguez, Beatriz B.,Chang, Mi Ra,Kuruvilla, Dana,Ciesla, Anthony,Abell, Andrew D.,Kamenecka, Theodore M.,Griffin, Patrick R.,Bruning, John B.
, p. 4584 - 4593 (2017)
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor central to fatty acid and glucose homeostasis. PPARγ is the molecular target for type 2 diabetes mellitus (T2DM) therapeutics TZDs (thiazolidinediones), full agonists of PPARγ with
Therapeutic modulation of PPARgamma activity
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Page/Page column 63, (2010/02/14)
Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.