315237-99-1Relevant academic research and scientific papers
Perfluoroalkylation in flow microreactors: Generation of perfluoroalkyllithiums in the presence and absence of electrophiles
Nagaki, Aiichiro,Tokuoka, Shinya,Yamada, Shigeyuki,Tomida, Yutaka,Oshiro, Kojun,Amii, Hideki,Yoshida, Jun-Ichi
, p. 7559 - 7563 (2011)
Perfluoroalkyllithiums were effectively generated from perfluoroalkyl halides in the presence and absence of electrophiles using flow microreactor systems. The in situ trapping with electrophile is conducted at much higher temperatures than those required for batch macro reactors. The subsequent trapping method is quite effective for highly reactive electrophiles that are not compatible with the lithiation process.
Method for Producing Fluorine-Containing Substituted Compound and Fluorine-Containing Substituted Compound
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Paragraph 0280-0282, (2014/02/15)
A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound.
