31525-75-4Relevant articles and documents
Synthesis and cytotoxicity of coumarin derivatives and nordentatin
Promsuwan, Pawantree,Yenjai, Chavi
, p. 3629 - 3632 (2013/05/09)
Nordentatin and 10 coumarin derivatives were synthesized and evaluated for cytotoxicity. Compounds 6, 7, 9 and 13 showed cytotoxicity against the NCI-H187 cell line with IC50 value ranging of 3-7 μg/mL. Among synthesized coumarins, compounds 4 and 13 demonstrated cytotoxicity against the KB cell line with IC50 values of 3.94 and 6.44 μg/mL, respectively. Fortunately, coumarins 4 and 7 may be one of the new lead compounds for the development of anticancer agents due to reason that they showed weak and inactive against normal cells.
SYNTHESIS OF NEW PYRANOCOUMARINS
Zawadowski, Teodor,Mazur, Andrzej,Kleps, Jerzy
, p. 547 - 552 (2007/10/02)
As a result of condensing 5,7-dihydroxy-4-methylcoumarin with dimethyl acetal-3-methylbuten-2-al, 4-methyl-5-hydroxyseseline, 4-methyldipetalolactone and 5-hydroxy-4,10,10-trimethyl-2H,8H-benzodipyran-2-one have been obtained.Condensation of 5,7-hydroxycoumarin with this acetal leads to 5-hydroxyseseline, dipetalolactone and 5-hydroxy-10,10-dimethyl-2H,8H-benzodipyran-2-one
EFFICIENT SYNTHESES OF THE COUMARINS, COUMURRAYIN, XANTHOXYLETIN AND TRACHYPHYLLIN
Murray, R. D. H.,Jorge, Z. D.
, p. 3403 - 3404 (2007/10/02)
The structure of the natural coumarin, trachyphyllin (12) has been confirmed by a total synthesis from 5,7-diacetoxycoumarin (1).Convenient synthetic routes to coumurrayin (5) and xanthoxyletin (10) have been established.