3154-99-2

Usage

Uses

Used in Pharmaceutical Industry:
2-cyclopropylbenzonitrile is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure and reactivity make it a promising candidate for the creation of innovative medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2-cyclopropylbenzonitrile is employed as a building block for the synthesis of agrochemicals, including insecticides. Its role in this industry is crucial for the development of effective pest control solutions.
Used in Dye and Pigment Production:
2-cyclopropylbenzonitrile is utilized as a starting material in the production of dyes and pigments, where its chemical properties are harnessed to create a wide range of colorants for various applications.
Used in Organic Synthesis and Pharmaceutical Research:
As a reagent in organic synthesis, 2-cyclopropylbenzonitrile is used for the preparation of various chemical products. Its versatility in reactions makes it an essential tool in pharmaceutical research for the exploration of new chemical entities and potential drug candidates.
However, it is important to note that 2-cyclopropylbenzonitrile is a toxic and irritant substance, and appropriate safety measures should be taken during its handling and use to minimize potential hazards.

Upstream product

• 1607-29-0 bis((1-methylcyclopropyl)formyl)peroxide 
• 100-47-0 benzonitrile 
• 2042-37-7 o-cyanobromobenzene 
• 23719-80-4 cyclopropylmagnesium bromide 
• 411235-57-9 cyclopropylboronic acid 

Downstream Products

• 134920-43-7 N-[1-(2-Cyano-phenyl)-propyl]-acetamide 
• 52186-76-2 ethyl cyclopropanecarbimidate 

Relevant academic research and scientific papers

Facile synthesis of aryl(het)cyclopropane catalyzed by palladacycle

Sphos (2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′- biphenyl) adduct of cyclopalladated ferrocenylimine (IIe) exhibited highly catalytic activity for the Suzuki cross-coupling reaction of cyclopropylboronic acid with aryl(het) halides with 1 mol % catalyst loading. This process was applied to both of aryl and heteroaryl halides (Br and Cl), and made the various arylcyclopropane and heteroarylcyclopropane to be easily synthesized. A variety of substituents on the aryl halides, such as alkyl, acetyl, benzoyl, ether, formyl, carboxylate, methoxy, nitro and cyano were tolerated.

Palladium-catalyzed cross-coupling of cyclopropylmagnesium bromide with aryl bromides mediated by zinc halide additives

The key Pd-catalyzed cross-coupling of aryl bromides or triflates and cyclopropylmagnesium bromide in the presence of substoichiometric amounts of zinc bromide produces cyclopropyl arenes in good to excellent yields. The cross-coupling of other alkyl, cyc

General and user-friendly protocol for the synthesis of functionalized aryl- and heteroaryl-cyclopropanes by Negishi cross-coupling reactions

The introduction of an unsubstituted cyclopropyl moiety was efficiently accomplished via Negishi cross-coupling of cyclopropylzinc bromide with functionalized aryl halides in high yields and fast reaction rates. The stability and the efficient one-step sy