31555-35-8

Upstream product

• 109-12-6 2-aminopyrimidine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 123466-30-8 [(4-methoxyphenyl)ethynyl](phenyl)iodonium tosylate 
• 875289-81-9 2,4-dinitro-benzenesulfonic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 909104-20-7 3-(2-fluorophenyl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyrimidine 
• 909104-18-3 3-(4-chlorophenyl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyrimidine 
• 500228-75-1 2-(4-methoxyphenyl)imidazo[1,2-a]pyrimidine-3-carbaldehyde 
• 60472-20-0 5-(4-methoxyphenyl)-1H-imidazol-2-ylamine 
• 1186493-20-8 3-benzyl-2-(4-methoxyphenyl)imidazo[1,2-a]pyrimidine 
• 60472-20-0 4-(4-methoxyphenyl)-1H-imidazol-2-ylamine 
• 134044-58-9 2-(4-Methoxy-phenyl)-3-nitro-imidazo[1,2-a]pyrimidine 
• 89185-49-9 2-(4-methoxyphenyl)imidazo[1,2-a]pyrimidin-3-amine 

Relevant academic research and scientific papers

ANTIBACTERIAL COMPOUNDS

The present invention relates to compounds of general formula (II),to compositions comprising these compounds and to methods of treating Enterobacteriaceae bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Enterobacteriaceae.

Synthesis and anti-inflammatory activity of 1,2-3-substituted 2a1,4,5-triazacyclopenta[cd]indene derivatives

The present study reports the synthesis of 1,2-3-substituted-2a1,4,5-triazacyclopenta[cd]indene derivatives. The synthetic methodology includes some of the prominent reaction steps as specified in sequence (i) Bromination of acetophenones (ii) Condensation of 2-bromo-1-(substituted phenyl) ethanone derivatives with 2-aminopyrimidine, and (iii) Coupling of imidazo[1,2-a]pyrimidine derivatives with 1,2-diaryl/diaklylethynes. The structures of the newly synthesized derivatives have been determined by 1H NMR, 13C NMR, LC-MS, and IR spectral analysis. Furthermore, these derivatives were screened for their preliminary anti-inflammatory activities using Carrageenan induced paw edema test method. These promising screening results suggested a huge potential for the molecular diversity from present compounds that can be inflated to better lead candidates.

Efficient Access to Imidazo[1,2- a] pyridines/pyrazines/pyrimidines via Catalyst-Free Annulation Reaction under Microwave Irradiation in Green Solvent

An expeditious catalyst-free heteroannulation reaction for imidazo[1,2-a]pyridines/pyrimidines/pyrazines was developed in green solvent under microwave irradiation. Using H2O-IPA as the reaction medium, various substituted 2-aminopyridines/pyra

Design, synthesis and biological evaluation of imidazopyridine/imidazopyrimidine-benzimidazole conjugates as potential anticancer agents

A series of imidazopyridine/imidazopyrimidine-benzimidazole conjugates (11a-t) were synthesized and evaluated for their antiproliferative activity. All of these conjugates showed moderate to improved cytotoxic activity against the human cervical (Hela), l

Structure-activity relationship of 4(5)-aryl-2-amino-1 H -imidazoles, N 1-substituted 2-aminoimidazoles and imidazo[1,2- a ]pyrimidinium salts as inhibitors of biofilm formation by salmonella typhimurium and pseudomonas aeruginosa

A library of 112 4(5)-aryl-2-amino-1H-imidazoles, 4,5-diphenyl-2-amino-1H- imidazoles, and N1-substituted 4(5)-phenyl-2-aminoimidazoles was synthesized and tested for the antagonistic effect against biofilm formation by Salmonella Typhimurium and Pseudomo

Tandem [8 + 2] cycloaddition-[2 + 6 + 2] dehydrogenation reactions involving imidazo[1,2- a ]pyridines and imidazo[1,2- a ]pyrimidines

The reaction between benzynes and imidazo[1,2-a]pyridines (pyrimidines) to form benzo[a]imidazo[5,1,2-cd]indolizines and 2,3,9c-triazocyclopenta[j,k] fluorenes has been studied computationally and experimentally. It is found that these reactions take plac

Hypervalent iodine(III) sulfonate mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines in liquid PEG-400

PEG-400[poly(ethylene glycol-400)] is used as a "green" recyclable solvent in the one-pot synthesis of 2-arylimidazo[1,2-a]pyrimidines by reaction with ketones, [hydroxyl(2,4-dinitrobenzenesulfonyloxy)-iodo]benzene (HDNIB), and 2-aminopyrimidine. Signific

Regiochemistry of the microwave-assisted reaction between aromatic amines and α-bromoketones to yield substituted 1H-indoles

The scope and regioselectivity of the Bischler (or Bischler-Moehlau) reaction between aromatic amines and α-bromoketones has been studied by computational and experimental techniques. It has been found that in many cases the reaction yields are improved under microwave irradiation and working in the absence of solvent. When di- and trisubstituted amines are used as substrates the regioselectivity of the reaction is different to that obtained with the corresponding primary anilines. The reaction between benzene-1,2-diamine and α-bromoacetophenones under the same conditions yields 2-substituted quinoxalines instead of indoles. Finally, when pyridin-2-amines and pyrimidine-2-amines are allowed to react with the corresponding α-bromoacetophenones, the corresponding imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines are obtained, respectively. The Royal Society of Chemistry.

A facile [hydroxy(tosyloxy)iodo]benzene mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines and their conversion into 3-bromo-2- arylimidazo[1,2-a]pyrimidines

α-Tosyloxyketone 2, obtained through hypervalent iodine oxidation of enolizable ketones using [hydroxy(tosyloxy)iodo]benzene (HTIB) in acetonitrile, on treatment with 2-aminopyrimidine 3 generates regioselectively 2-arylimidazo[1,2-a]pyrimidine 6 which up

Organic reactions in ionic liquids: Ionic liquid-accelerated one-pot synthesis of 2-arylimidazo[1,2-a]pyrimidines

The room-temperature ionic liquid n-butylpyridinium tetrafluoroborate (BPyBF4) is used as a recyclable alternative to classical molecular solvents in the one-pot synthesis of 2-arylimidazo[1,2-a]pyrimidines by reaction with ketones, [hydroxy(tosyloxy)iodo]benzene, and 2-aminopyrimidine. Significant rate enhancements and improved yields have been observed. Copyright Taylor & Francis, Inc.