315663-45-7

Upstream product

• 114652-98-1 2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)acetic acid 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 

Downstream Products

• 206854-38-8 (6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester 
• 206854-08-2 C₂₄H₂₈N₆O₈S 
• 206854-63-9 (6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester 
• 315663-51-5 (6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid 3-methyl-benzyl ester 
• 75007-70-4 decarboxy-moxalactam 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors

1-Oxacephem derivatives were synthesized and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 1-oxacephems led to compound 34, which exhibited 6 nM inhibition of human chymase and high selectivity for human chymase compared to other serine enzymes. (C) 2000 Elsevier Science Ltd.