75007-70-4

Upstream product

• 86862-88-6 (6R,7R)-7-[2-(4-Benzyloxycarbonyloxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 315663-45-7 (6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 114652-98-1 2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)acetic acid 
• 156-38-7 4-hydroxyphenylacetate 
• 66510-99-4 (6R,7R)-benzhydryl-7-amino-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 86862-92-2 diphenylmethyl <4-<(benzyloxycarbonyl)oxy>phenyl>acetate 
• 86862-84-2 Carbonic acid benzyl ester 4-chlorocarbonylmethyl-phenyl ester 
• 86862-83-1 <4-<(benzyloxycarbonyl)oxy>phenyl>acetic acid 
• 78984-21-1 diphenylmethyl (4-hydroxyphenyl)acetate 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 64952-97-2 moxalactam 

Downstream Products

• 206854-38-8 (6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester 
• 206854-63-9 (6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester 
• 315663-51-5 (6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid 3-methyl-benzyl ester 

Relevant academic research and scientific papers

Degradation and epimerization kinetics of moxalactam in aqueous solution

The kinetics of epimerization and degradation of moxalactam in aqueous solution was investigated by HPLC. The pH-rate profiles of the degradation and epimerization were determined separately over the pH range of 1.0-11.5 at 37°C and constant ionic strength 0.5. The degradation and simultaneous epimerization were followed by measuring both of the residual R- and S-epimers of moxalactam and were found to follow pseudo-first-order kinetics. The degradation was subjected to hydrogen ion and hydroxide ion catalyses and influenced by the dissociation of the side chain phenolic group. The epimerization rates were influenced significantly in the acidic region by the dissociation of the side chain carboxylic acid group and in the basic region by hydroxide ion catalysis. The pH-degradation rate profile of moxalactam showed a minimum degradation rate constant between pH 4.0 and 6.0. The pH-epimerization rate profiles of moxalactam showed minimum epimerization rate constants at pH 7.0. The epimerization rate constant of the R- and S-epimers were not very different.

Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors

1-Oxacephem derivatives were synthesized and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 1-oxacephems led to compound 34, which exhibited 6 nM inhibition of human chymase and high selectivity for human chymase compared to other serine enzymes. (C) 2000 Elsevier Science Ltd.

Synthesis and Substituent Effects on Antibacterial Activity, Alkaline Hydrolysis Rates, and Infrared Absorption Frequencies of Some Cephem Analogues Related to Latamoxef (Moxalactam)

Relationships between intrinsic antibacterial activity and β-lactam reactivity of 7β-amino- and 7β-amino derivatives of 1-oxa- and 1-thiacephems, with or without the 7α-methoxy group (1-8), were investiga