315665-53-3

Upstream product

• 276679-06-2 C₅₂H₆₅N₆O₁₃PSi 
• 40733-27-5 3'-O-(t-butyldimethylsilyl)thymidine 
• 276679-09-5 diisopropyl-phosphoramidous acid 3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-cyano-ethyl ester 
• 315665-51-1 3'-O-(t-butyldimethylsilyl)-5'-O-[H-(2-cyanoethyl)phosphonyl]thymidine 
• 246538-35-2 3-[(2S,3S,5R)-3-Benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propionic acid ethyl ester 
• 246538-19-2 3'-C-carbobenzyloxyamino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5'(R)-C-hydroxyethylthymidine 
• 246538-23-8 3'-C-amino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3-N,5'(R)-C-ethylenethymidine 
• 246538-18-1 3'-C-carbobenzyloxyamino-3'-deoxy-5'(R,S)-C-ethoxycarbonylmethylthymidine 
• 246538-17-0 3'-C-carbobenzyloxyamino-3'-deoxythymidine 
• 246538-34-1 [(2S,3S,5R)-2-Formyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-carbamic acid benzyl ester 
• 52450-18-7 3'-amino-3'-deoxythymidine 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 

Relevant academic research and scientific papers

Conformationally locked nucleosides. Synthesis of oligodeoxynucleotides containing 3'-amino-3'-deoxy-3'-N,5'(R)-C-ethylenethymidine

3'-Amino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-N,5'(R)-C-ethylenethymidine (6) was synthesized starting from 3'-azido-3'-deoxythymidine. Condensation of 6 with 5'-O-(H-phosphonyl)thymidine and 5'-O-(p-nitrophenoxycarbonyl)thymidine derivatives gave dinucleotide and dinucleoside derivatives, respectively, which were incorporated into oligodeoxynucleotides (ODNs). Tm data of the modified ODNs are also presented.