C₄₆H₅₁N₆O₁₃P

Base Information

Chemical Name:C₄₆H₅₁N₆O₁₃P
CAS No.:315665-53-3
Molecular Formula:C₄₆H₅₁N₆O₁₃P
Molecular Weight:926.917
Hs Code.:

C<sub>46</sub>H<sub>51</sub>N<sub>6</sub>O<sub>13</sub>P

Synonyms:C₄₆H₅₁N₆O₁₃P

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₄₆H₅₁N₆O₁₃P

Chemical Property:

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Technology Process of C₄₆H₅₁N₆O₁₃P

There total 13 articles about C₄₆H₅₁N₆O₁₃P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52450-18-7
3'-amino-3'-deoxythymidine

: 315665-53-3
C₄₆H₅₁N₆O₁₃P

Guidance literature:: Multi-step reaction with 9 steps

1.1: 27.3 g / Na₂CO₃ / H₂O / 0 - 20 °C

2.1: 88 percent / DCC; DMSO; TFA / diethyl ether; pyridine / 5 h / 20 °C

3.1: Zn powder / tetrahydrofuran / 0.5 h / 45 °C

3.2: 61.9 percent / tetrahydrofuran / 20 h / 42 - 45 °C

4.1: 91 percent / AgNO₃ / pyridine / 34 h / 55 °C

5.1: 4.83 g / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

6.1: 3.28 g / DMAP / pyridine / 5 h / 20 °C

7.1: 1.51 g / H₂; Et₃N / ethanol / 22 h / 20 °C / 2585.74 Torr

8.1: Et₃N / acetonitrile; CH₂Cl₂; CCl₄ / 0.5 h / 20 °C

9.1: TBAF; AcOH / tetrahydrofuran / 24 h / 20 °C / pH 5.5

With dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; silver nitrate; acetic acid; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In tetrahydrofuran; pyridine; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; acetonitrile; 1.1: Acylation / 2.1: Oxidation / 3.1: Metallation / 3.2: Reformatsky reaction / 4.1: tritylation / 5.1: Reduction / 6.1: Tosylation / 7.1: Hydrogenolysis / 8.1: Condensation / 9.1: desilylation;
DOI:10.1080/15257770008033851

Reference yield:

: 276679-06-2
C₅₂H₆₅N₆O₁₃PSi

: 315665-53-3
C₄₆H₅₁N₆O₁₃P

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 24h; pH=5.5;
DOI:10.1080/15257770008033851

Reference yield:

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 315665-53-3
C₄₆H₅₁N₆O₁₃P

Guidance literature:: Multi-step reaction with 10 steps

1.1: H₂ / Pd/C / methanol / 4 h / 20 °C / 2844.31 Torr

2.1: 27.3 g / Na₂CO₃ / H₂O / 0 - 20 °C

3.1: 88 percent / DCC; DMSO; TFA / diethyl ether; pyridine / 5 h / 20 °C

4.1: Zn powder / tetrahydrofuran / 0.5 h / 45 °C

4.2: 61.9 percent / tetrahydrofuran / 20 h / 42 - 45 °C

5.1: 91 percent / AgNO₃ / pyridine / 34 h / 55 °C

6.1: 4.83 g / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

7.1: 3.28 g / DMAP / pyridine / 5 h / 20 °C

8.1: 1.51 g / H₂; Et₃N / ethanol / 22 h / 20 °C / 2585.74 Torr

9.1: Et₃N / acetonitrile; CH₂Cl₂; CCl₄ / 0.5 h / 20 °C

10.1: TBAF; AcOH / tetrahydrofuran / 24 h / 20 °C / pH 5.5

With dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; silver nitrate; acetic acid; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; acetonitrile; 1.1: Reduction / 2.1: Acylation / 3.1: Oxidation / 4.1: Metallation / 4.2: Reformatsky reaction / 5.1: tritylation / 6.1: Reduction / 7.1: Tosylation / 8.1: Hydrogenolysis / 9.1: Condensation / 10.1: desilylation;
DOI:10.1080/15257770008033851