315688-72-3Relevant academic research and scientific papers
Synthesis of some new formazanyl-thiazolyl-indoles and formazanyl-oxazolyl-indoles as inflammation inhibitors
Bansal,Srivastava,Kumar
, p. 357 - 362 (2007/10/03)
Various 3-(2-arylideneaminothiazol-4-yl)indoles 3a-e and 3-(2-arylideneaminooxazol-4-yl)indoles 3a'-e' on diazotisation with aniline afford 3-[2-(1'-phenyl-3'-substituted-aryl-formazan-4'-yl)thiazol-4-yl] indoles 4a-e and 3-[2-(1'-substituted-phenyl-3'-substituted aryl-formazan-4'-yl)oxazol-4-yl]indoles 4a'-e' respectively. All the compounds have shown interesting antiinflammatory activity in carrageenan induced oedema in rats at 50 mg/kg p.o. The most active compound in the series is 3-[2-(o-methoxybenzylidene)aminothiazol-4-yl]indole which has shown higher antiinflammatory activity and lower ulcerogenic property than phenylbutazone.
