31570-97-5

Basic information

• Product Name: 5-HYDROXY-2(1H)-QUINOLINONE
• Synonyms: 5-HYDROXY-2(1H)-QUINOLINONE;5-Hydroxy-1H-quinolin-2-one;5-HYDROXY-2(1H)-QUINILINONE;5-Hydroxyquinolin-2(1H)-one;1,2-Dihydro-5-hydroxy-2-oxoquinoline;5-hydroxy-1,2-dihydroquinolin-2-one;5-Hydroxy-2(1H)-quinolone;5-Hydroxycarbostyril
• CAS NO: 31570-97-5
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Product Categories: pharmacetical;Aromatics;Heterocycles
• Mol File: 31570-97-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 402.4 °C at 760 mmHg
• Flash Point: 197.2 °C
• Appearance: /
• Density: 1.337 g/cm³
• Vapor Pressure: 4.73E-07mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 8.65±0.20(Predicted)
• CAS DataBase Reference: 5-HYDROXY-2(1H)-QUINOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXY-2(1H)-QUINOLINONE(31570-97-5)
• EPA Substance Registry System: 5-HYDROXY-2(1H)-QUINOLINONE(31570-97-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 31570-97-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Solid

Uses

5-Hydroxyquinolin-2(1H)-one (cas# 31570-97-5) is a compound useful in organic synthesis.

InChI:InChI=1/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-5,11H,(H,10,12)

Upstream product

• 578-67-6 quinolin-5-ol 
• 5057-12-5 3,4,7,8-tetrahydro-2,5(1H,6H)-quinolinequinone 
• 15450-69-8 5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone 
• 88877-00-3 5-acetyl-6-(2-dimethylaminoethenyl)-2(1H)-pyridinone 

Downstream Products

• 124467-35-2 2-chloro-5-hydroxyquinoline 
• 15450-73-4 2,5,8(1H)-quinolinetrione 
• 160893-04-9 5-methoxy-2(1H)-quinolinone 
• 1374108-95-8 C₂₂H₂₆N₂O₃ 
• 1374108-94-7 C₃₆H₃₈N₂O₃ 
• 1374108-93-6 C₂₆H₂₄ClNO₃ 
• 1374108-50-5 C₂₉H₃₁FN₂O₂ 
• 1374108-49-2 C₂₀H₁₇F₄NO₅S 
• 1374107-18-2 2-(4-diethylaminophenyl)-5-(1-(fluoromethyl)-2-hydroxyethoxy)quinoline 
• 1374107-45-5 2-(4-diethylaminophenyl)-5-(2-hydroxy-1-tosyloxymethylethoxy)quinoline 
• 1374108-48-1 C₁₉H₁₈FNO₃ 
• 75928-26-6 N-Cyclohexyl-N-ethyl-4-(2-oxo-1,2-dihydro-quinolin-5-yloxy)-butyramide 
• 64330-12-7 N-methyl-5-methoxy-2(1H)-quinolinone 
• 160893-06-1 5-hydroxy-2-methoxyquinoline 

Relevant articles and documents

Novel synthesis of 1,6-naphthyridin-2(6H)-ones, quinolin-2(1H)-ones, and quino[7,8-f]quinoline-2,9(1H,10H)-dione from common precursors

1,6-Naphthyridin-2(6H)-ones 3, quinolin-2(1H)-ones 5, and quino[7,8-f]quinoline-2,9(1H,10H)-dione 10 have been synthesized from 5-acyl-6-[2-(dimethylamino)ethenyl]pyridin-2(1H)-ones 1.

SYNTHESIS OF 5-METHOXY-2(1H)-QUINOLINONE

Methylation of 5-hydroxy-2(1H)quinolinone (1) is studied.The previous protection of the amide group in 1 is proposed as the more convenient method to obtain 5-methoxy-2(1H)-quinolinone (1a).