31570-97-5

Usage

Uses

Used in Organic Synthesis:
5-HYDROXY-2(1H)-QUINOLINONE is used as a key intermediate in organic synthesis for the production of various chemical compounds and pharmaceuticals. Its presence in the synthesis process allows for the creation of a wide range of molecules with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-HYDROXY-2(1H)-QUINOLINONE is used as a building block for the development of new drugs and therapeutic agents. Its unique chemical properties enable the design and synthesis of novel compounds with potential medicinal properties.
Used in Chemical Research:
5-HYDROXY-2(1H)-QUINOLINONE is also utilized in chemical research as a model compound to study various chemical reactions and mechanisms. Its reactivity and stability make it an ideal candidate for understanding complex chemical processes and developing new synthetic methodologies.
Used in Material Science:
In the field of material science, 5-HYDROXY-2(1H)-QUINOLINONE is employed in the development of new materials with specific properties. Its incorporation into the synthesis of polymers, coatings, and other materials can lead to the creation of innovative products with improved performance characteristics.
Overall, 5-HYDROXY-2(1H)-QUINOLINONE is a versatile compound with a wide range of applications across various industries, including organic synthesis, pharmaceuticals, chemical research, and material science. Its unique properties and reactivity make it an essential component in the development of new products and technologies.

InChI:InChI=1/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-5,11H,(H,10,12)

Upstream product

• 5057-12-5 3,4,7,8-tetrahydro-2,5(1H,6H)-quinolinequinone 
• 15450-69-8 5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone 
• 578-67-6 quinolin-5-ol 
• 88877-00-3 5-acetyl-6-(2-dimethylaminoethenyl)-2(1H)-pyridinone 

Downstream Products

• 64330-12-7 N-methyl-5-methoxy-2(1H)-quinolinone 
• 160893-06-1 5-hydroxy-2-methoxyquinoline 
• 160893-04-9 5-methoxy-2(1H)-quinolinone 
• 15450-73-4 2,5,8(1H)-quinolinetrione 
• 75928-26-6 N-Cyclohexyl-N-ethyl-4-(2-oxo-1,2-dihydro-quinolin-5-yloxy)-butyramide 
• 124467-35-2 2-chloro-5-hydroxyquinoline 
• 1374108-95-8 C₂₂H₂₆N₂O₃ 
• 1374108-94-7 C₃₆H₃₈N₂O₃ 
• 1374108-93-6 C₂₆H₂₄ClNO₃ 
• 1374108-50-5 C₂₉H₃₁FN₂O₂ 
• 1374108-49-2 C₂₀H₁₇F₄NO₅S 
• 1374107-18-2 2-(4-diethylaminophenyl)-5-(1-(fluoromethyl)-2-hydroxyethoxy)quinoline 
• 1374107-45-5 2-(4-diethylaminophenyl)-5-(2-hydroxy-1-tosyloxymethylethoxy)quinoline 
• 1374108-48-1 C₁₉H₁₈FNO₃ 

Relevant academic research and scientific papers

Novel synthesis of 1,6-naphthyridin-2(6H)-ones, quinolin-2(1H)-ones, and quino[7,8-f]quinoline-2,9(1H,10H)-dione from common precursors

1,6-Naphthyridin-2(6H)-ones 3, quinolin-2(1H)-ones 5, and quino[7,8-f]quinoline-2,9(1H,10H)-dione 10 have been synthesized from 5-acyl-6-[2-(dimethylamino)ethenyl]pyridin-2(1H)-ones 1.

O-prenylated carbostyrils as a novel class of 15-lipoxygenase inhibitors: Synthesis, characterization, and inhibitory assessment

Catalyzed peroxidation of unsaturated lipid in animals and plants intimately is linked to the activity of 15-Lipoxygenase enzymes. Lipoxygenases (LOXs) are well known to play an important role in many acute and chronic syndromes such as inflammation, asthma, cancer, and allergy. In this study, a series of mono prenyloxycarbostyrils were synthesized and evaluated as potential inhibitors of soybean 15-Lipoxygenase (SLO) and their inhibitory potencies were compared to mono prenyloxycoumarins which had been reported in the previous works. The synthetic compounds inhibit lipoxygenase enzyme by competitive mechanism like the prenyloxy coumarins. The results showed that position and length of the prenyl moiety play the important role in lipoxygenase inhibitory activity. Among all of the synthetic compounds (coumarin and carbostyril derivatives), 5-farnesyloxycoumarin and 8-farnesyloxycarbostyril demonstrated the best inhibitory activity by IC50?values of 1.1?μM and 0.53?μM, respectively.

SYNTHESIS OF 5-METHOXY-2(1H)-QUINOLINONE

Methylation of 5-hydroxy-2(1H)quinolinone (1) is studied.The previous protection of the amide group in 1 is proposed as the more convenient method to obtain 5-methoxy-2(1H)-quinolinone (1a).