31589-45-4

Upstream product

• 1476-53-5 sodium novobiocin 
• 91393-52-1 2,2-dimethyl-chroman-6-carbonyl chloride 
• 3780-29-8 4,7-dihydroxy-3-amino-8-methylcoumarin hydrochloride 

Downstream Products

• 2039-47-6 2,2-dimethylchroman-6-carboxylic acid 
• 3780-30-1 7-acetoxy-2,6-dimethyl-chromeno[3,4-d]oxazol-4-one 
• 1000006-68-7 4TCNA 
• 1000006-71-2 toluene-4-sulfonic acid 3-[(2,2-dimethylchroman-6-carbonyl)amino]-4-hydroxy-8-methyl-2-oxo-2H-chromen-7-yl ester 
• 1620841-80-6 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 1620841-68-0 N-(4-hydroxy-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide 
• 1620841-82-8 6-bromo-3-(2,2-dimethylchroman-6-carboxamido)-7-hydroxy-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 1620838-64-3 3-(2,2-dimethylchroman-6-carboxamido)-7-(2,3,4,6-tetra-O-acetyl-β-glucopyranos-1-yl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 1620841-79-3 3-(2,2-dimethylchroman-6-carboxamido)-6-ethynyl-7-methoxy-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 1620841-78-2 6-(3-(dimethylamino)prop-1-ynyl)-3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 1620841-76-0 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-((3,4,5-trimethoxyphenyl)ethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 1620841-75-9 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-((4-methoxyphenyl)ethynyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 1620841-74-8 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-8-methyl-2-oxo-6-(phenylethynyl)-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 1620841-64-6 N-(4-hydroxy-7-methoxy-8-methyl-2-oxo-6-((3,4,5-trimethoxyphenyl)ethynyl)-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide 

Relevant academic research and scientific papers

Synthesis and antiproliferative activity of novobiocin analogues as potential hsp90 inhibitors Dedicated to the memory of Dr. Christine Radanyi.

A series of substituted coumarins1-10 was designed and synthesized as a novel class of 4TCNA analogues. Compound 2a showed excellent antiproliferative activity with mean GI50 values at a micromolar level in a diverse set of human cancer cells (

New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90

Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins involved in cell proliferation and survival, angiogenesis, and metastasis. Investigation of novobiocin analogues lacking the noviose moiety as novel inhibitors of hsp