31591-86-3 Usage
Uses
Used in Pharmaceutical Industry:
1-H-PYRAZOLO[3,4-B]PYRIDIN-4-OL is used as a therapeutic agent for cognitive impairments associated with neurodegenerative diseases such as Alzheimer's disease. Its agonistic action on the α7 nicotinic acetylcholine receptor is believed to enhance cognitive function and potentially slow the progression of these diseases.
1-H-PYRAZOLO[3,4-B]PYRIDIN-4-OL is also used as a potential treatment for psychiatric disorders. The modulation of the α7 nicotinic acetylcholine receptor by 1-H-PYRAZOLO[3,4-B]PYRIDIN-4-OL may contribute to the management of various psychiatric conditions by influencing neurotransmission and synaptic plasticity.
In Pain Management Applications:
1-H-PYRAZOLO[3,4-B]PYRIDIN-4-OL is used as an analgesic agent, leveraging its interaction with the α7 nicotinic acetylcholine receptor to potentially alleviate chronic and neuropathic pain by modulating pain signaling pathways.
For Inflammation Treatment:
1-H-PYRAZOLO[3,4-B]PYRIDIN-4-OL is utilized as an anti-inflammatory agent, where its agonistic effect on the α7 receptor may help in reducing inflammation by influencing immune cell function and cytokine production.
Overall, 1-H-PYRAZOLO[3,4-B]PYRIDIN-4-OL's diverse applications across different therapeutic areas highlight its potential as a versatile compound in the development of novel pharmaceuticals targeting the α7 nicotinic acetylcholine receptor for various health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 31591-86-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,5,9 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 31591-86:
(7*3)+(6*1)+(5*5)+(4*9)+(3*1)+(2*8)+(1*6)=113
113 % 10 = 3
So 31591-86-3 is a valid CAS Registry Number.
31591-86-3Relevant academic research and scientific papers
Gas-phase synthesis of pyrazolo[3,4- b ]pyridin-4-ones
Mackay, Martha,Nortcliffe, Andrew,McNab, Hamish,Hulme, Alison N.
, p. 242 - 248 (2015/05/05)
Flash vacuum pyrolysis (FVP) at 500-600 °C of 1-substituted pyrazolylaminomethylene derivatives of Meldrum's acid provides 1-substituted pyrazolo[3,4-b]pyridin-4-ones in high yields. If the 1-substituent is a tert-butyl group, FVP at 750-850 °C causes elimination of 2-methyl-1-propene to give the parent pyrazolo[3,4-b]pyridin-4-one.
Unambiguous Synthesis of 4,7-Dihydro-4-oxo-1H-pyrazolopyridine - Further Comments on the "(N-C)-Rearrangement" of (2-Alkoxycarbonyl-vinylamino)pyrazols
Dorn, Helmut,Ozegowski, Ruediger
, p. 557 - 562 (2007/10/02)
4,7-Dihydro-4-oxo-1H-pyrazolopyridine 1a is synthesized by decarboxylation of 1-benzyl-5-carboxy-4-hydroxy-pyrazolopyridine 4b and debenzylation of 1-benzyl-4,7-dihydro-4-oxo-pyrazolopyridine 1b with sodium in liquid ammonia.The produ
