316-81-4 Usage
Originator
Majeptil,Specia,France,1960
Definition
ChEBI: A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.
Manufacturing Process
A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100
cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1-
piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is
added and the mixture heated under reflux for 5 hours. After treatment of the
reaction products, a crude oily base (2.5 g) is obtained after treatment. By
the addition of a solution of fumaric acid in ethanol to an ethanolic solution of
the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)-
phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The
base recrystallized from ethyl acetate melts at about 140°C.
Therapeutic Function
Neuroleptic, Antiemetic
Check Digit Verification of cas no
The CAS Registry Mumber 316-81-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 316-81:
(5*3)+(4*1)+(3*6)+(2*8)+(1*1)=54
54 % 10 = 4
So 316-81-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3