31609-82-2

Upstream product

• 37975-15-8 1-(3'-nitrophenyl)-3-phenylpropane-1,3-dione 
• 6968-99-6 m-nitrobenzalacetophenone dibromide 
• 6969-00-2 benzal-m-nitroacetophenone dibromide 
• 5447-87-0 2-(1-phenylethylidene)propanedinitrile 
• 33512-94-6 m-nitrobenzhydroxamoyl chloride 
• 67-56-1 methanol 
• 7732-18-5 water 
• 536-74-3 phenylacetylene 
• 1616956-18-3 (Z)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one O-methyl oxime 
• 3431-62-7 3-nitrobenzaldoxime 
• 99-61-6 3-nitro-benzaldehyde 
• 16616-39-0 1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one 
• 88596-60-5 (+/-)-1-(3-nitrophenyl)-3-phenylprop-2-yn-1-ol 
• 6969-00-2 (2RS:3SR)-2.3-dibromo-3-phenyl-1-(3-nitro-phenyl)-propanone-⁽¹⁾ 

Relevant academic research and scientific papers

3, 5-disubstituted isoxazole derivative and synthesis method thereof

The invention provides a 3, 5-disubstituted isoxazole derivative and a synthesis method thereof, and belongs to the technical field of organic synthesis medicines and medical intermediates. The method comprises the following steps: adding a proper solvent

Catalyst control in positional-selective C-H alkenylation of isoxazoles and a ruthenium-mediated assembly of trisubstituted pyrroles

High levels of catalyst control are demonstrated in determining the positional selectivity in C-H alkenylation of isoxazoles. A cationic rhodium-mediated, strong-directing group promotes C(sp2)-H activation at the proximal aryl ring whereas, the palladium-mediated electrophilic metallation leads to the C(sp2)-H activation at the distal position of the directing group. Synthetic elaboration of this C-H alkenylation product via ruthenium and copper co-catalysis leads to an efficient method for the assembly of densely substituted pyrroles.

Direct synthesis of 4-fluoroisoxazoles through gold-catalyzed cascade cyclization-fluorination of 2-alkynone O-methyl oximes

A tandem protocol for the synthesis of fluorinated isoxazoles has been developed via catalytic intramolecular cyclizations of 2-alkynone O-methyl oximes and ensuing fluorination. The reactions proceed smoothly at room temperature in the presence of 5 mol

BENZO-γ-PYRONES. PART VIII. REACTION OF CHALCONE DIBROMIDES AND β-DIKETONES WITH HYDROXYLAMINE

In the reaction of some chalcone dibromides and unsymmetrically substituted diaroylmethanes with hydroxylamine formation of mixture of isomeric isoxazoles was observed and the percentage content of each isomer was established.A new mechanism is proposed for the reaction of β-diketones with hydroxylamine, based on enolic form in accordance with expected substituents effect.