3161-80-6Relevant academic research and scientific papers
Synthesis, X-ray analysis, biological evaluation and molecular docking study of new thiazoline derivatives
Mabkhot, Yahia N.,Algarni,Alsayari, Abdulrhman,Muhsinah, Abdullatif Bin,Kheder, Nabila A.,Almarhoon, Zainab M.,Al-Aizari, Faiz A.
, (2019/05/24)
A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing1H-NMR,13C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.
Simple method for the preparation of dialkyl (2,3-dihydro-1,3-thiazol-2-YL) -phosphonates
Janikowska, Karolina,Makowiec, Slawomir
experimental part, p. 12 - 20 (2011/03/20)
A simple synthesis of dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates from thiazolium salts and trialkyl phosphites is described. The series of dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates with various substituents in positions 3, 4, and 5 of the thiazole ring were prepared. However, only phosphonates with an aryl on the nitrogen atom were stable enough for chromatographic purification, although all the new phosphonates are very sensitive to oxidation. We made efforts to apply dialkyl (2,3-dihydro-1,3- thiazol-2-yl)-phosphonates in a Horner-Wadsworth-Emmons reaction, but the generated antiaromatic anion of phosphonate decomposed quickly, even at -70°C. Copyright Taylor & Francis Group, LLC.
Synthesis and heterocyclization of dithiocarbamoylacetoacetic esters and anilides
Dovlatyan,Eliazyan,Pivazyan,Ghazaryan,Engoyan,Grigoryan,Mirzoyan
, p. 593 - 597 (2007/10/03)
The action of salts of N-monosubstituted dithiocarbamic acids on α-chloroacetoacetic ester and the corresponding anilide led to the isolation of the α-dithiocarbamoyl derivatives. These derivatives are converted, on standing or heating, to the ethyl ester
The Reaction of Active Methylene Reagents With Sulfur and Phenyl Isothiocyanate: Novel Synthesis of Thiazole, Thiazolopyrimidine, and 4,5'-Bithiazolyl Derivatives
Mohareb, Rafat Milad,Wardakhan, Wagnat Wahba,El-Ablack, Fawzia Zakeria
, p. 747 - 760 (2007/10/02)
The active methylene reagents 1a-i reacted with phenyl isothiocyanate and sulfur to afford the thiazole derivatives 2a-i.The reactivity of 2a and 2f towards various chemical reagents was studied.
