316123-29-2 Usage
Molecular weight
427.52 g/mol
Chemical structure
1-Pyrrolidinecarboxylic acid, 4-(dimethylamino)-2-[[4-(methoxycarbonyl)phenoxy]methyl]-, 1,1-dimethylethyl ester, (2S,4S)-
Medicinal use
Treatment of high blood pressure and heart failure
Mechanism of action
Selective beta-1 adrenergic receptor blocker with nitric oxide-potentiating vasodilatory effects
Route of administration
Oral
Common side effects
Dizziness, fatigue, headache
Available forms
Prescription under various brand names
Check Digit Verification of cas no
The CAS Registry Mumber 316123-29-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,6,1,2 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 316123-29:
(8*3)+(7*1)+(6*6)+(5*1)+(4*2)+(3*3)+(2*2)+(1*9)=102
102 % 10 = 2
So 316123-29-2 is a valid CAS Registry Number.
316123-29-2Relevant academic research and scientific papers
4-(Pyrrolidinyl)methoxybenzoic acid derivatives as a potent, orally active VLA-4 antagonist
Chiba, Jun,Iimura, Shin,Yoneda, Yoshiyuki,Sugimoto, Yuichi,Horiuchi, Takao,Muro, Fumito,Ochiai, Yuichi,Ogasawara, Tomomi,Tsubokawa, Masao,Iigou, Yutaka,Takayama, Gensuke,Taira, Tomoe,Takata, Yoshimi,Yokoyama, Mika,Takashi, Tohru,Nakayama, Atsushi,Machinaga, Nobuo
, p. 1515 - 1529 (2007/10/03)
A novel series of benzoic acid derivatives as VLA-4 antagonists were synthesized. Optimization, focusing on activity and lipophilicity needed for cell permeability, resulted in the identification of 15b and 15e with good activity (IC50=1.6 nM each) and moderate lipophilicity (Log D=2.0, 1.8). Furthermore, 15e demonstrated efficacy in murine asthma model by an oral dose of 30 mg/kg.
