31637-96-4

Basic information

• Product Name: etofibrate 2-hydroxymethyl-2-(4-chlorophenoxy)-2-methyl propionate
• Synonyms: etofibrate 2-hydroxymethyl-2-(4-chlorophenoxy)-2-methyl propionate;PROPANOIC ACID 2-(4-CHLOROPHENOXY)-2-METHYL-,2-HYDROXYETHYL ESTER
• CAS NO: 31637-96-4
• Molecular Formula: C₁₂H₁₅ClO₄
• Molecular Weight: 258.6981
• Mol File: 31637-96-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 387.1°Cat760mmHg
• Flash Point: 187.9°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 1.1E-06mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: etofibrate 2-hydroxymethyl-2-(4-chlorophenoxy)-2-methyl propionate(CAS DataBase Reference)
• NIST Chemistry Reference: etofibrate 2-hydroxymethyl-2-(4-chlorophenoxy)-2-methyl propionate(31637-96-4)
• EPA Substance Registry System: etofibrate 2-hydroxymethyl-2-(4-chlorophenoxy)-2-methyl propionate(31637-96-4)

Safety Data

• Hazardous Substances Data: 31637-96-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15ClO4/c1-12(2,11(15)16-8-7-14)17-10-5-3-9(13)4-6-10/h3-6,14H,7-8H2,1-2H3

Upstream product

• 31637-97-5 ETOFIBRATE 

Relevant articles and documents

Disposition of etofibrate, clofibric and nicotinic acid esters, and their products in dogs

Etofibrate, the ethylene glycol diester of clofibric and nicotinic acids, on intravenous infusion into dogs, has a terminal half-life of 2 min. The intermediate half-esters, the nicotinate and the clofibrate, have respective terminal half-lives of 4.6 and 1.7 min and appear fleetingly when etofibrate is administered. In contrast to the 42-h terminal half-life of clofibric acid, the other final transformation product, nicotinic acid, shows saturable or dose-dependent pharmacokinetics in dogs that conform to the Michaelis-Menten equation with a terminal half-life of 4.4 min at low concentrations ( 6.9 μM/kg). Three distinct metabolites of nicotinic acid can be identified and assayed chromatographically in the urine. The partition properties were similar to nicotinic acid. Nicotinic acid is excreted 30% unchanged into urine with a renal clearance of 70 mL/min in 27-kg dogs.