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31637-97-5 Usage


Etofibrate is a hypolipidemic agent, which is a combination of niacin and clofibrate. It is a white to off-white solid that effectively reduces lipid levels in the blood by decreasing plasma cholesterol and triglyceride concentrations. In addition to its primary function, etofibrate also has beneficial effects on thromboxane formation, platelet aggregation, plasma viscosity, and inhibits neointima formation in a carotid artery balloon injury rat model. Formulations containing etofibrate are commonly used to treat hyperlipidemia.


Used in Pharmaceutical Industry:
Etofibrate is used as an antilipemic agent for reducing lipid levels in the blood. It is particularly effective in lowering plasma cholesterol and triglyceride concentrations, which helps in the treatment of hyperlipidemia.
Used in Cardiovascular Health:
Etofibrate is used to decrease thromboxane formation, platelet aggregation, and plasma viscosity. These properties contribute to its role in maintaining cardiovascular health and preventing complications associated with high lipid levels.
Used in Research and Development:
Etofibrate's ability to inhibit neointima formation in a carotid artery balloon injury rat model makes it a valuable compound for research and development in the field of vascular biology and the study of atherosclerosis.


Etofibrate ,under the trade name Lipo-Merz, is a broad-spectrum efficient lipid regulating drug . Etofibrate is a compound formed by clofibrate and nicotinic acid , after administration,in the body,it is decomposed into clofibrate and niacin,and plays its role quickly, and the effect is long, which is characterized by inhibiting the synthesis of cholesterol and triglycerides, increasing excretion of sterols fecal ,it is clinically mainly used for lowering plasma triglycerides. It is used for the treatment of hyperlipidemia (severe primary and secondary hyperlipidemia), arterial pulse atherosclerosis, cerebral vascular disorder and the end vascular disorder,vascular and retinal vascular disease, it is used for the prevention of stroke, heart attack, myocardial infarction, high blood pressure, high cholesterol and obesity, blood circulation disorders.Etofibrate is developed by the German Merz company,it belongs to phenoxy acetic acids and nicotinic acid lipid regulation drugs, it is used for hyperlipidemia ,it is listed in Germany, France, Italy, but currently it is not yet listed in China. The above information is edited by the lookchem of Tian Ye.


Lipo-Merz,Merz,W. Germany,1974

Manufacturing Process

A stream of ethylene oxide is passed through a solution of 107 g of 2-(pchlorophenoxy)- 2-methylpropionic acid and 2 g of zinc chloride in 200 ml of toluene, previously heated to between 55°C and 60°C, until 24 g of the gas have been dissolved. The reaction is allowed to continue for five hours, with gentle stirring. After this time has elapsed, the solution is cooled and washed successively with water, dilute ammonia and water until its pH becomes neutral. It is dried over anhydrous sodium sulfate, the solvent is separated off under vacuum, and the resulting liquid is the monoglycol ester of 2-(pchlorophenoxy)- 2-methylpropionic acid.The product thus prepared is sufficiently pure to be used in the subsequent reaction. In this way, 107 g of the ester are prepared, which represents a yield of 83%.To a solution of 93.8 g of the monoglycol ester in 500 ml of benzene, there are added 55 g of nicotinic acid chloride and 25 g of trimethylamine dissolved in 200 ml of benzene. The solution is stirred gently at a temperature of 60°C for two hours. After this time, the solution is cooled and washed successively with water, dilute hydrochloric acid, dilute ammonia and water until neutrality, it is dried over anhydrous sodium sulfate, and the solvent is evaporated under vacuum: in this way 110 g of glycol 2-(p-chlorophenoxy)-2-methylpropionate nicotinate is prepared, which represents a yield of 84%. The product is a slighly yellow oil having a refraction index of nD 20 =1.5422 and which is distilled with decomposition at 214°C at a pressure of 0.3 mm.

Therapeutic Function


Check Digit Verification of cas no

The CAS Registry Mumber 31637-97-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,6,3 and 7 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 31637-97:
115 % 10 = 5
So 31637-97-5 is a valid CAS Registry Number.

31637-97-5 Well-known Company Product Price

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  • Sigma-Aldrich

  • (90013)  Etofibrate  analytical standard

  • 31637-97-5

  • 90013-25MG

  • 916.11CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017


1.1 GHS Product identifier

Product name 2-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxyethyl pyridine-3-carboxylate

1.2 Other means of identification

Product number -
Other names Etofibrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:31637-97-5 SDS

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