57743-13-2

Usage

Uses

Used in Pharmaceutical Industry:
2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID is utilized as a building block in the creation of agrochemicals, which are essential for enhancing crop protection and yield.
Used in Organic Synthesis:
2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID is employed as a key component in organic synthesis, where its functional groups facilitate the formation of a wide range of chemical compounds for various applications.
Used in Drug Discovery:
2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID is also used in drug discovery as a potential candidate for anti-inflammatory and anti-cancer properties, indicating its importance in the research and development of novel therapeutic agents.

Upstream product

• 110-86-1 pyridine 
• 14140-04-6 phenanthrene-9,10-dione oxime 
• 98-09-9 benzenesulfonyl chloride 
• 6747-35-9 2-carboxy-2'-(aminocarboxyl)-1,1'-biphenyl 
• 120007-30-9 2'-cyano-2-biphenylcarbonyl chloride 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 69339-02-2 N-t-Butyl-2,2'-diphenamidsaeure 
• 3942-85-6 10-imino-10H-phenanthren-9-one 
• 96794-13-7 9-hydroxy-10-nitroso-phenanthrene 
• 120007-29-6 O-(2'-cyano-2-biphenylylcarbonyl)-9,10-phenathrenequinone oxime 
• 2042-37-7 o-cyanobromobenzene 
• 149105-19-1 2-carboxyphenylboronic acid 
• 16419-60-6 2-Methylphenylboronic acid 

Downstream Products

• 4733-28-2 10-Hydroxy-phenanthridin-1-carbonsaeurelacton 
• 31638-34-3 2'-aminomethylbiphenyl-2-carboxylic acid 

Relevant academic research and scientific papers

MASS-SPECTROMETRIC BEHAVIOR OF 9-HYDROXY-10-NITROSOPHENANTHRENE AND ITS DIAZA ANALOGS

According to mass-spectral data, 9-hydroxy-10-nitrosophenanthrene in the gas phase exists primarily in this tautomeric form rather than in the 9-oxo-10-hydroxyimino tautomeric form, while passing to its 4,5-diaza and, particularly, its 1,8-diaza analogs shifts the equilibrium sharply to favor the o-quinoid form.The character of the fragmentation of the molecular ions of the polycyclic compounds differs markedly from the fragmentation of the acyclic rearrangement product - 2-carboxy-2'-cyanobiphenyl.

Cobalt-Catalyzed Biaryl Couplings via C-F Bond Activation in the Absence of Phosphine or NHC Ligands

A highly general and selective Co-catalyzed biaryl coupling through C-F cleavage under phosphine or NHC-free conditions was described. A broad range of aryl fluorides including unactivated fluorides as well as those with sensitive functionalities could couple with various Ti(OEt)4-mediated aryl Grignard reagents with high selectivity under the catalysis of CoCl2/DMPU. Importantly, selective C-F bond activation couplings between two types of fluorines (difluorinated aromatics and on two different coupling partners) and in the presence of C-Cl or C-Br bonds could also be achieved.

Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen

A room temperature phosphine or NHC ligand-free cobalt-catalyzed arylation of (hetero)aromatic acids has been developed. It involves an oxidative cross-coupling between carboxylate and aryl titanate reagents using oxygen as an oxidant, and the arylation at the position ortho, meta and para to the carboxylic acid group could all be achieved. As application, various (hetero)aromatic acids including xenalipin, tafamidis and the key intermediate for a cardioprotective compound have been efficiently synthesized.

A practical preparation of 2-carboxyphenylboronic acid and its application for the preparation of biaryl-2-carboxylic acids using Suzuki coupling reactions

A practical synthesis of 2-carboxyphenylboronic from 2-tolylboronic acid and aqueous potassium permanganate under mild conditions is reported. The title compound couples with aryl bromides containing electron-withdrawing groups to give biaryl-2-carboxylic

BECKMANN REARRANGEMENT OF 9,10-PHENANTHRENEQUINONE MONOXIME WITH TOLUENESULFONYL CHLORIDE IN THE PRESENCE OF BASES

The degree of rearrangement of 9,10-phenanthrenequinone monoxime with p-toluenesulfonyl chloride in the presence of the pyridine in an amount close to stoichiometric is reduced on account of the formation of O-(2'-cyano-2-biphenylylcarbonyl)-9,10-phenanth

Synthesis and antifibrinolytic properties of some ε aminoacids

The authors have synthesized some ε aminoacids and investigated their antifibrinolytic activity. Two of them, α aminocampholic acid and d,1 cis 2,2 dimethyl α 3 aminoethyl) cyclobutane acetic acid, which are prepared by catalytic hydrogenation of respective cyanoacid and oxime acid possess an activity slightly superior to that of ε aminocaproic acid actually used in therapy.