31642-67-8

Basic information

• Product Name: 8-NONENOIC ACID
• Synonyms: 8-NONENOIC ACID;NONENOIC ACID (8-);8-Nonenoic acid 97%
• CAS NO: 31642-67-8
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.22
• Mol File: 31642-67-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 2.5°C
• Boiling Point: 274.02°C (estimate)
• Flash Point: >110℃
• Appearance: /
• Density: 0.908 g/mL at 25 °C
• Vapor Pressure: 0.00385mmHg at 25°C
• Refractive Index: n20/D1.444
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: 8-NONENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 8-NONENOIC ACID(31642-67-8)
• EPA Substance Registry System: 8-NONENOIC ACID(31642-67-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 31642-67-8(Hazardous Substances Data)

Usage

Uses

8-?Nonenoic Acid is a reagent used in the synthesis of 4-N-Alkyl Gemcitabine (G305000) analogs, which act as antineoplastics.

Synthesis Reference(s)

Synthetic Communications, 9, p. 63, 1979 DOI: 10.1080/00397917908064130

InChI:InChI=1/C9H16O2/c1-2-3-4-5-6-7-8-9(10)11/h2H,1,3-8H2,(H,10,11)

Upstream product

• 39200-19-6 nona-3,8-dienoic acid 
• 4117-09-3 7-bromo-hept-1-ene 
• 105-53-3 diethyl malonate 

Downstream Products

• 610308-51-5 1,2-di-(8'-nonenoyl)-3-(p-methoxybenzyl)-sn-glycerol 
• 13038-22-7 non-8-en-1-yl acetate 
• 1197213-40-3 C₅₉H₈₈O₁₃Si₂ 
• 1470259-79-0 C₂₂H₃₀N₂O₆ 
• 505-48-6 octane-1,8-dioic acid 
• 112-05-0 nonanoic acid 
• 3710-30-3 1,7-Octadiene 
• 30505-89-6 Piperolein B 
• 62510-52-5 1-[1-oxo-9-(3,4-methylenedioxyphenyl)-8E-nonenyl]-pyrrolidine 

Relevant articles and documents

Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof

The invention provides a process of preparing 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Compound I and pharmaceutically acceptable salts thereof.

Novel regioselective hydrogenation of alkadienoic acids caused by the addition of water

The regioselective hydrogenation of 3,8-nonadienoic acid to 8-nonenoic acid was realized by the addition of water with RhCl[P(p-tolyl)3]3 in benzene at 1 atm hydrogen, whereas in the absence of water the reaction mostly gave 3-nonenoic acid. The novel selectivity is caused by both an accelerating effect of water on the hydrogenation of the 3-position and a retarding effect on that of the 8-position.