31651-76-0

Basic information

• Product Name: DICHLOROPHOSPHONIC ACID-[1]NAPHTHYL ESTER
• Synonyms: DICHLOROPHOSPHONIC ACID-[1]NAPHTHYL ESTER;Dichloridophosphoric acid 1-naphtyl ester;Dichlorophosphinic acid 1-naphtyl ester;Phosphorodichloridic acid 1-naphtyl ester
• CAS NO: 31651-76-0
• Molecular Formula: C₁₀H₇Cl₂O₂P
• Molecular Weight: 261.04
• Mol File: 31651-76-0.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 199-201 °C(Press: 20 Torr)
• Appearance: /
• Density: 1.466±0.06 g/cm3(Predicted)
• CAS DataBase Reference: DICHLOROPHOSPHONIC ACID-[1]NAPHTHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: DICHLOROPHOSPHONIC ACID-[1]NAPHTHYL ESTER(31651-76-0)
• EPA Substance Registry System: DICHLOROPHOSPHONIC ACID-[1]NAPHTHYL ESTER(31651-76-0)

Safety Data

• Hazardous Substances Data: 31651-76-0(Hazardous Substances Data)

Usage

General Description

DICHLOROPHOSPHONIC ACID-[1]NAPHTHYL ESTER is a chemical compound with the molecular formula C14H10Cl2O3P. It is commonly used as an intermediate in the production of phosphorus-containing pesticides, flame retardants, and plasticizers. DICHLOROPHOSPHONIC ACID-[1]NAPHTHYL ESTER can be toxic to humans and the environment, and exposure to it should be minimized. It is important to handle and use DICHLOROPHOSPHONIC ACID-[1]NAPHTHYL ESTER with caution and in accordance with safety guidelines to prevent any adverse effects on health and the environment. Additionally, proper disposal methods should be followed to avoid contaminating soil and water sources.

Upstream product

• 90-15-3 α-naphthol 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 691411-31-1 (1R,3S,5S)-2,4-Dibenzyl-1,8,8-trimethyl-3-(naphthalen-1-yloxy)-2,4-diaza-3-phospha-bicyclo[3.2.1]octane 3-oxide 
• 874362-22-8 1-naphthyl-(methoxy-L-phenylalaninyl)phosphochloridate 
• 1255860-44-6 (2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate 
• 1234489-08-7 (2S)-cyclohexyl 2-((chloro(naphthalen-1-yloxy)phosphoryl)amino)propanoate 
• 1431557-61-7 2-amino-2’-fluoro-2’-deoxyadenosine-5’-O-naphthyl(cyclohexoxy-L-alaninyl)phosphate 
• 1431557-60-6 2-amino-2’-fluoro-2’-deoxyadenosine-5’-O-naphthyl(benzoxy-L-alaninyl)phosphate 
• 1431557-55-9 2’-deoxy-2’-fluoro-6-chloroguanosine-5’-O-naphthyl(benzoxy-L-alaninyl)phosphate 
• 1431558-38-1 6-O-ethyl-2’-fluoro-2’-deoxyguanosine-5’-O-naphthyl(benzoxy-L-alaninyl)phosphate 
• 1431557-47-9 6-O-methyl-2’-fluoro-2’-deoxyguanosine-5’-O-naphtyl(cyclohexoxy-L-alaninyl)phosphate 
• 1431557-46-8 6-O-methyl-2’-fluoro-2’-deoxyguanosine-5’-O-naphthyl(benzoxy-L-alaninyl)phosphate 
• 1444431-01-9 (S)-2-[[(2R,3S,4S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-4-(tert-butyl-diphenyl-silanyloxy)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-(naphthalen-1-yloxy)-phosphorylamino]-propionic acid isopropyl ester 
• 1444430-56-1 (S)-2-[[(2R,3S,4S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3-fluoro-4-hydroxy-tetrahydro-furan-2-ylmethoxy]-(naphthalen-1-yloxy)-phosphorylamino]-propionic acid benzyl ester 
• 906670-24-4 1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate 

Relevant articles and documents

Structural Effects in Phosphates. 1. Comparison of 4-Nitrophenyl 1-Naphthyl and 4-Nitrophenyl Quinolin-8-yl Phosphates

Crystal and molecular structures of quinolin-8-yl bis(p-nitrophenyl) (4), quinolin-8-yl p-nitrophenyl (4a), and 1-naphthyl bis(p-nitrophenyl) phosphates (5) have been determined and compared.In 4 the donor-acceptor nitrogen-phosphorus interactions change the geometry of the molecule from tetrahedral to quasi-tbp, so the structure can be considered as an "early stage" of the intramolecular displacement of the PNPO group.In 4a this interaction is replaced by intramolecular N:H:O hydrogen bonding.The intramolecular nonbonded potential energies of 4 and 5 were calculated, and the minimum-energy conformations obtained were compared with those determined by X-ray diffraction.The results of calculations confirm the observed differences in the intramolecular interactions operating in 4 and 5.The mass spectra of 4 and 5 reveal a dramatic difference between these two phosphates with respect to the fragmentation involving the expulsion of the p-nitrophenoxy radical and the formation of the corresponding phosphorylium ion by the nitrogen atom.Rate measurements for the base-catalyzed hydrolysis of the P-OPNP linkage show that 4 is not significantly more reactive than 5 and provide no evidence for the intramolecular nucleophilic catalysis in the hydrolysis of 4.

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Deuterated compound and application thereof in treatment of cancer

The present invention relates to a deuterated compound and application thereof in the treatment of cancer. Specifically, the present invention provides the compound of formula (I) and pharmaceuticallyacceptable salt or ester thereof, and a pharmaceutical composition thereof. The compound and the pharmaceutical composition are used for inhibiting or regulating the activity of tyrosine kinase and treating disease symptoms or symptoms including cancer mediated by tyrosine kinase.

PRODRUGS OF A CDK INHIBITOR FOR TREATING CANCERS

There are provided compounds of Formula I, and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for inhibition or modulation of the activity of cyclin dependent kinases (CDK) and/or glycogen synthase kinase-3 (GSK-3), for the treatment of disease states or conditions mediated by cyclin dependent kinases and/or glycogen synthase kinase-3, including cancers. (I)