31676-54-7

Basic information

• Product Name: 5-PHENYL-PYRIDIN-3-YLAMINE
• Synonyms: 3-AMINO-5-PHENYLPYRIDINE;5-PHENYL-PYRIDIN-3-YLAMINE;3-Pyridinamine, 5-phenyl-;5-phenylpyridin-3-aMine
• CAS NO: 31676-54-7
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.21
• Mol File: 31676-54-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 389.4 °C at 760 mmHg
• Flash Point: 217.7 °C
• Appearance: /
• Density: 1.133 g/cm³
• Vapor Pressure: 2.86E-06mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.78±0.20(Predicted)
• CAS DataBase Reference: 5-PHENYL-PYRIDIN-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-PYRIDIN-3-YLAMINE(31676-54-7)
• EPA Substance Registry System: 5-PHENYL-PYRIDIN-3-YLAMINE(31676-54-7)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 31676-54-7(Hazardous Substances Data)

Usage

General Description

5-PHENYL-PYRIDIN-3-YLAMINE, also known as 5-Phenylpyridin-3-ylamine or 5-(Pyridin-3-yl)aniline, is a chemical compound with the molecular formula C11H10N2. It is a yellowish powder that is used in the synthesis of pharmaceutical products and organic compounds. As an aromatic amine, it is used as a building block for the production of various drugs and agrochemicals. This chemical is also used in the development of new materials and in research laboratories as a reagent for chemical reactions. Furthermore, it is important to handle 5-PHENYL-PYRIDIN-3-YLAMINE with caution as it may cause skin and eye irritation, and should be stored and used in a well-ventilated area.

InChI:InChI=1/C11H10N2/c12-11-6-10(7-13-8-11)9-4-2-1-3-5-9/h1-8H,12H2

Upstream product

• 25391-60-0 2-chloro-3-iodo-5-nitropyridine 
• 1119088-46-8 2-chloro-5-nitro-3-phenylpyridine 
• 25391-58-6 2-hydroxy-3-iodo-5-nitropyridine 
• 22353-34-0 5-chloropyridin-3-amine 
• 98-80-6 phenylboronic acid 
• 13535-01-8 3-amino-5-bromopyridine 

Downstream Products

• 1338435-89-4 2-butyl-5-(5-phenylpyridin-3-ylamino)isoindolin-1-one 

Relevant articles and documents

UREA DERIVATIVES AS CB1 ALLOSTERIC MODULATORS

Heteroaryl and aliphatic analogs of diarylurea-based cannabinoid 1 receptor (CB1 R) allosteric modulators of formula (I) are described. Exemplary analogs can provide improved potencies and pharmacokinetic properties. Methods of using the analogs to treat

Discovery of a potent, cell penetrant, and selective p300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) bromodomain chemical probe

P300/CREB binding protein associated factor (PCAF/KAT2B) and general control nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in retroviral infection, inflammation pathways, and cancer development. However, outside of viral replication, little is known about the dependence of these effects on the C-terminal bromodomain. Herein, we report GSK4027 as a chemical probe for the PCAF/GCN5 bromodomain, together with GSK4028 as an enantiomeric negative control. The probe was optimized from a weakly potent, nonselective pyridazinone hit to deliver high potency for the PCAF/GCN5 bromodomain, high solubility, cellular target engagement, and ≥18000-fold selectivity over the BET family, together with ≥70-fold selectivity over the wider bromodomain families.

Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.