316790-75-7

Upstream product

• 32338-02-6 2-bromo-4-methoxyaniline 
• 4023-34-1 cyclopropanecarboxylic acid chloride 

Downstream Products

• 659743-65-4 N-(2-bromo-4-methoxyphenyl)-N-methylcyclopropanecarboxamide 
• 1426327-90-3 N-(2-bromo-4-methoxyphenyl)-N-(cyclopropylmethyl)-1,1,1-trifluoromethanesulfonamide 
• 316790-80-4 cyclopropanecarboxylic acid allyl-(2-bromo-4-methoxy-phenyl)-amide 

Relevant academic research and scientific papers

Synthesis of functionalized spiroindolines via palladium-catalyzed methine C-H arylation

The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp3)-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of heteroaromatics to access functionalized indoline scaffolds in a single step.

Silver-promoted, palladium-catalyzed direct arylation of cyclopropanes: Facile access to spiro 3,3′-cyclopropyl oxindoles

The Pd-catalyzed, Ag(I)-mediated intramolecular direct arylation of cyclopropane C-H bonds is described. Various spiro 3,3′-cyclopropyl oxindoles can be obtained in good to excellent yields from easily accessible 2-bromoanilides. The kinetic isotope effect was determined and epimerization studies were conducted, suggesting that the formation of a putative Pd-enolate is not operative and that the reaction proceeds via a C-H arylation pathway.

A novel synthesis of spirocyclic pyrrolidin-2-ones

A short synthesis of a series of spirocyclic pyrrolidin-2-ones is presented which proceeds via initial [1,5]-radical translocation followed by cyclisation. (C) 2000 Elsevier Science Ltd.