316807-96-2

Upstream product

• 3430-31-7 3-bromo-2,6-dimethylpyridine 

Downstream Products

• 316808-03-4 2,6-bis-(tetr-butyl-dimethyl-silanyloxymethyl)-3-[4S-(4-methoxy-benzyloxy)-5R-(4-methoxy-benzyloxy-methyl)-tetrahydro-furan-2R-yl]-pyridine 
• 671791-91-6 3-{5R-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4S-hydroxy-tetrahydro-furan-2R-yl}-pyridine-2,6-dicarboxylic acid dimethyl ester 
• 316808-05-6 3-[4S-(4-methoxy-benzyloxy)-5R-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2R-yl]-pyridine-2,6-dicarboxylic acid 
• 316808-06-7 3-[4S-(4-methoxy-benzyloxy)-5R-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2R-yl]-pyridine-2,6-dicarboxylic acid dimethyl ester 
• 316808-04-5 {6-hydroxymethyl-3-[4S-(4-methoxy-benzyloxy)-5R-(4-methoxy-benzyloxy-methyl)-tetrahydro-furan-2R-yl]-pyridin-2-yl}-methanol 
• 316807-99-5 1S-[2,6-bis-(tetr-butyl-dimethyl-silanyloxymethyl)-pyridin-3-yl]-3S,4R,5-tris-(4-methoxy-benzyloxy)-pentan-1-ol 

Relevant academic research and scientific papers

A second-generation copper(II)-mediated metallo-DNA-base pair

Metal-dependent pairing of nucleobases represents an alternative DNA base pairing scheme. Our first-generation copper(II)-mediated pyridine-2,6- dicarboxylate (Dipic) and pyridine (Py) metallo-base pair has a stability comparable to the natural base pairs dA:dT and dC:dG but does not have the selectivity of the Watson Crick base pairs. In order to increase the selectivity of base pair formation, a second-generation metallo-base pair was generated consisting of a pyridine-2,6-dicarboxamide (Dipam) and a pyridine (Py) nucleobase. This new metallo-base pair is more stable than the natural base pairs dA:dT and dC:dG and highly selective against mispairing. In addition, incorporation of multiple metallo-base pairs into DNA results in the formation of stable duplexes demonstrating that hydrogen bonding base pairs can efficiently be replaced by metal-dependent base pairs at multiple sites in DNA.