3430-31-7

Basic information

• Product Name: 3-Bromo-2,6-dimethylpyridine
• Synonyms: 3-BROMO-2,6-DIMETHYLPYRIDINE;3-Bromo-2,6-dimethylpyridine 98%;2,6-Dimethylpyridine-3-Bromopyridine;2,6-Dimethyl-3-bromopyridine;3-Bromo-2,6-dimethylpyridine ,97%;3-Bromo-2,6-dimethyl;3-Bromo-6-methyl-2-picoline;3-BroMo-2,6-diMethylpyridine 98%, 6-diMethylpyridine 98%
• CAS NO: 3430-31-7
• Molecular Formula: C₇H₈BrN
• Molecular Weight: 186.05
• EINECS: 1592732-453-0
• Product Categories: Pyridine;Pyridine Series;Heterocycle-Pyridine series
• Mol File: 3430-31-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 56-58°C 2mm
• Flash Point: 86℃
• Appearance: /
• Density: 1.431 g/mL at 25 °C
• Vapor Pressure: 0.615mmHg at 25°C
• Refractive Index: n20/D1.552
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.32±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2,6-dimethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2,6-dimethylpyridine(3430-31-7)
• EPA Substance Registry System: 3-Bromo-2,6-dimethylpyridine(3430-31-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-36/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 3430-31-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8BrN/c1-5-3-4-7(8)6(2)9-5/h3-4H,1-2H3

Upstream product

• 108-48-5 2,6-dimethylpyridine 
• 625-84-3 2,5-Dimethylpyrrole 
• 75-25-2 Bromoform 

Downstream Products

• 116651-89-9 2,6-dimethyl-3-methylsulfonylpyridine 1-oxide 
• 116651-88-8 2,6-dimethyl-3-methylsulfinylpyridine 1-oxide 
• 116651-86-6 2,6-dimethyl-3-methylthiopyridine 1-oxide 
• 116651-90-2 2,6-dimethyl-3-methylsulfinylpyridine 
• 116651-87-7 2,6-dimethyl-3-methylthiopyridine 
• 99471-59-7 6-(2,6-dimethylpyridin-3-yl)-8-(methylthio)-2(1H)-quinolinone 0.25 hydrate 
• 99471-56-4 8-bromo-3,4-dihydro-6-(2,6-dimethylpyridin-3-yl)-2(1H)-quinolinone 
• 99471-63-3 8-hydroxy-6-[2,6-dimethylpyrid-3-yl]-2-(1H)-quinolone 
• 99454-99-6 8-bromo-6-[2,6-dimethyl-pyrid-3-yl]-2-(1H)-quinolone 
• 99470-97-0 8-methyl-6-[2,6-dimethylpyrid-3-yl]-2-(1H)-quinolone 
• 99470-91-4 6-(2,6-dimethylpyridin-3-yl)-2(1H)-quinolinone 
• 99471-49-5 3,4-dihydro-6-[2,6-dimethylpyrid-3-yl]-2-(1H)-quinolone 
• 137778-12-2 3-bromo-2,5-dimethyl-5-hydroxypyridine 

Relevant articles and documents

PRODRUGS OF KALLIKREIN INHIBITORS

Disclosed are compounds of formula I, II, and III, and pharmaceutically acceptable salts thereof, which are inhibitors of kallikrein. Also provided are pharmaceutical compositions comprising such a compound, and methods involving use of the compounds and compositions in the treatment and prevention of acquired or hereditary angioedema, or other diseases and conditions characterized by aberrant kallikrein activity. (I) (II) (III)

3D Structure Determination of an Unstable Transient Enzyme Intermediate by Paramagnetic NMR Spectroscopy

Enzyme catalysis relies on conformational plasticity, but structural information on transient intermediates is difficult to obtain. We show that the three-dimensional (3D) structure of an unstable, low-abundance enzymatic intermediate can be determined by nuclear magnetic resonance (NMR) spectroscopy. The approach is demonstrated for Staphylococcus aureus sortase A (SrtA), which is an established drug target and biotechnological reagent. SrtA is a transpeptidase that converts an amide bond of a substrate peptide into a thioester. By measuring pseudocontact shifts (PCSs) generated by a site-specific cysteine-reactive paramagnetic tag that does not react with the active-site residue Cys184, a sufficient number of restraints were collected to determine the 3D structure of the unstable thioester intermediate of SrtA that is present only as a minor species under non-equilibrium conditions. The 3D structure reveals structural changes that protect the thioester intermediate against hydrolysis.

The Bromination of Lutidines

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