316830-80-5

Upstream product

• 191849-93-1 3(S)-(N-tert-butoxycarbonylamino)-2(R,S)-hydroxy-4-phenylbutyric acid 
• 64-04-0 phenethylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 186393-18-0 ((S)-1-benzyl-2-cyano-2-hydroxy-ethyl)-carbamic acid tert-butyl ester 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 72155-45-4 Boc-L-phenylalaninal 
• 209173-80-8 2(RS)-hydroxy-3(S)-amino-4-phenylbutanoic acid 

Downstream Products

• 316830-81-6 3(S)-3-amino-2(RS)-hydroxy-N-phenethyl-4-phenylbutanamide 
• 910482-12-1 2(R)-N-((2S)-3(RS)-hydroxy-4-oxo-4-(phenethylamino)-1-phenylbutan-2-yl)-1-tosyl-pyrrolidine-2-carboxamide 
• 910482-14-3 2(R)-N-((2S)-3(RS)-hydroxy-4-oxo-4-(phenethylamino)-1-phenylbutan-2-yl)-1-(4-methoxy-phenylsulfonyl)pyrrolidine-2-carboxamide 
• 910482-13-2 2(R)-N-((2S)-3(RS)-hydroxy-4-oxo-4-(phenethylamino)-1-phenylbutan-2-yl)-1-(4-nitro-phenylsulfonyl)pyrrolidine-2-carboxamide 
• 316830-82-7 [(S)-1-((S)-1-Benzyl-2-hydroxy-2-phenethylcarbamoyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester 
• 316830-85-0 [(1S,2S)-1-((S)-1-Benzyl-2-hydroxy-2-phenethylcarbamoyl-ethylcarbamoyl)-2-isopropyl-cyclopropyl]-carbamic acid benzyl ester 
• 316830-83-8 [(1S,2R)-1-((S)-1-Benzyl-2-hydroxy-2-phenethylcarbamoyl-ethylcarbamoyl)-2-isopropyl-cyclopropyl]-carbamic acid benzyl ester 
• 316830-84-9 [(1R,2S)-1-((S)-1-Benzyl-2-hydroxy-2-phenethylcarbamoyl-ethylcarbamoyl)-2-isopropyl-cyclopropyl]-carbamic acid benzyl ester 
• 316830-86-1 [(1R,2R)-1-((S)-1-Benzyl-2-hydroxy-2-phenethylcarbamoyl-ethylcarbamoyl)-2-isopropyl-cyclopropyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis, calpain inhibitory activity, and cytotoxicity of P 2-substituted proline and thiaproline peptidyl aldehydes and peptidyl α-ketoamides

Calpain is a cytosolic cysteine endopeptidase that has been implicated in a number of disorders including cancer. We have synthesized and studied the μ-calpain inhibitory activity and cytotoxicity of peptidyl aldehydes and peptidyl α-ketoamides with N-sub

Significance of hydrogen bonding at the S1′ subsite of calpain I

α-Ketohydroxamates were synthesized as bioisosteres of α-ketoamides. The α-ketohydroxamates were generally more potent than the corresponding α-ketoamides. The potency of the compounds suggests that hydrogen bonding and steric bulk of substituents on the nitrogen atom of the ketoamide moiety influence calpain inhibition.

Synthesis and calpain inhibitory activity of α-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position

A series of novel ketoamides incorporating all four 2,3-methanoleucine stereoisomers at the P2 position was synthesized. The compounds displayed a wide variation in K(i) values for inhibition of calpain I depending on the configuration of the P