317-27-1Relevant academic research and scientific papers
Detection of ligands from a dynamic combinatorial library by X-ray crystallography
Congreve, Miles S.,Davis, Deborah J.,Devine, Lindsay,Granata, Cesare,O'Reilly, Marc,Wyatt, Paul G.,Jhoti, Harren
, p. 4479 - 4482 (2003)
A dynamic combinatorial library of ligands derived from hydrazines A and isatins B was assembled in the presence of crystals of the target protein, cyclin-dependent kinase 2 (CDK2). Unambiguous detection of potent ligands, formed as part of the library, was successfully achieved by X-ray crystallographic analysis.
