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317-34-0

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Product FOB Price Min.Order Supply Ability Supplier
Aminophylline
Cas No: 317-34-0
USD $ 17.0-22.0 / Kilogram 1 Kilogram 500 Kilogram/Month Greenutra Resource Inc Contact Supplier
Aminophylline Manufacturer/High quality/Best price/In stock
Cas No: 317-34-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Various Specifications Aminophylline CAS:317-34-0
Cas No: 317-34-0
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Manufacturer supply Aminophylline (anhydrous) CAS 317-34-0 of BP/USP standard
Cas No: 317-34-0
USD $ 12.0-20.0 / Kilogram 25 Kilogram 50 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Aminophylline manufacturer with low price
Cas No: 317-34-0
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Top Qualit CAS 317-34-0 Aminophylline Powder Price
Cas No: 317-34-0
USD $ 15.0-30.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Aminophylline
Cas No: 317-34-0
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Aminophylline hydrate
Cas No: 317-34-0
No Data 5 Milligram Gram/Day Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd Contact Supplier
Aminophylline
Cas No: 317-34-0
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
Factory Supply Aminophylline
Cas No: 317-34-0
No Data 100 Gram 4000 Metric Ton/Day Ality Chemical Corporation Contact Supplier

317-34-0 Usage

Description

Aminophylline is a drug combination consisting of bronchodilator theophylline and ethylenediamine in 2: 1 ratio. It is a kind of non-selective adenosine receptor blocker, histone deacetylase activator and phosphodiesterase inhibition. It is mainly indicated for the treatment of various kinds of lung diseases including asthma, COPD, chronic bronchitis and emphysema. Aminophylline exerts its effect through the component of theophylline in vivo. Theophylline can relax the smooth muscle of the bronchial airways and pulmonary blood vessels. It can competitively inhibits type III and type IV phosphodiesterase (PDE), which breaks down cyclic AMP in smooth muscle cells, possibly leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor to block the adenosine mediated bronchoconstriction. Furthermore, during the inflammatory states, theophylline can activate the histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones to initiate the transcription.

Brand name

Phyllocontin (Purdue Frederick); Somophyllin (Fisons); Truphylline (G & W).

Chemical Properties

white to slightly yellowish powder

References

https://www.drugbank.ca/drugs/DB01223 https://en.wikipedia.org/wiki/Aminophylline

Uses

Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.

Uses

Bronchodilatator;Mastocytes degranulation inhibitor

Contact allergens

This drug is a 2:1 mixture of the alkaloid theophylline and ethylenediamine (see below). It caused contact dermatitis in industrial plants, pharmacists, and nurses. Ethylenediamine is the sensitizer and patch testing is generally positive to both ethylenediamine and aminophylline and negative to theophylline.
InChI:InChI=1/2C7H8N4O2.C2H8N2.H2O/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4;/h2*3H,1-2H3,(H,8,9);1-4H2;1H2

317-34-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Aminophylline

1.2 Other means of identification

Product number -
Other names lasodex

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:317-34-0 SDS

317-34-0Synthetic route

theophylline
58-55-9

theophylline

ethylenediamine
107-15-3

ethylenediamine

theophylline ethylenediamine
317-34-0

theophylline ethylenediamine

Conditions
ConditionsYield
In methanol; ethyl acetate at 5 - 80℃; for 2.5h; Temperature;91.8%
sodium 1,2-naphthoquinone-4-sulfonate
521-24-4

sodium 1,2-naphthoquinone-4-sulfonate

theophylline ethylenediamine
317-34-0

theophylline ethylenediamine

2C7H8N4O2*C22H20N2O4

2C7H8N4O2*C22H20N2O4

Conditions
ConditionsYield
In sodium hydroxide at 40℃; pH=13.00; Kinetics; Further Variations:; Temperatures;

317-34-0Upstream product

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