317318-61-9

Basic information

• Product Name: (E)-3-{2-Methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-acrylic acid methyl ester
• Synonyms: (E)-3-{2-Methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-acrylic acid methyl ester
• CAS NO: 317318-61-9
• Molecular Weight: 447.478
• Mol File: 317318-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-{2-Methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-acrylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-{2-Methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-acrylic acid methyl ester(317318-61-9)
• EPA Substance Registry System: (E)-3-{2-Methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-acrylic acid methyl ester(317318-61-9)

Safety Data

• Hazardous Substances Data: 317318-61-9(Hazardous Substances Data)

Upstream product

• 175277-03-9 4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester 
• 317318-96-0 [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol 
• 72505-21-6 4-trifluoromethylbenzthioamide 
• 14472-14-1 4-bromo-3-methylphenol 
• 317319-05-4 3-(4-hydroxy-2-methylphenyl)acryl acid methyl ester 
• 317318-97-1 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole 

Relevant articles and documents

Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity

We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.