317318-99-3

Upstream product

• 475480-98-9 4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide 
• 1891-90-3 p-trifluoromethylbenzamide 
• 317318-98-2 4-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-5-carboxylic acid ethyl ester 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 109544-12-9 [4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-yl]-methanol 

Downstream Products

• 317318-45-9 {4-[4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid methyl ester 
• 317318-49-3 {2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethoxy]-phenoxy}-acetic acid methyl ester 
• 317318-67-5 {2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid methyl ester 

Relevant academic research and scientific papers

A highly regioselective preparation of 4-chloromethyl-5-methyl-2-aryl-1,3- oxazoles

A facile highly regioselective process is described for the formation of 4-chloromethyl-1,3-oxazoles from 1,3-oxazole N-oxide/HCl salts. An explanation is presented for the high regioselectivity in deoxygenation-chlorination using POCl3 with HC

A new approach to the synthesis of 2-aryl-4-halomethyl-5-methyl-1,3- oxazoles by highly regioselective direct halogenation with NBS or NCS/MeCN

A simple and efficient method for the synthesis of 2-aryl-4-bromomethyl-5- methyl-1,3-oxazoles 2 and 2-aryl-4-chloromethyl-5-methyl-1,3-oxazoles 3 is described. The reaction of 2-aryl-4,5-dimethyl-1,3-oxazoles 1 with N-bromosuccinimide and N-chlorosuccini

Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity

We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.