317319-15-6Relevant articles and documents
Acryloyl group-containing nuclear transport modulator and uses thereof
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Paragraph 0153-0156, (2020/09/12)
The invention relates to a novel acryloyl-containing compound as well as a preparation method and application thereof. Specifically, the invention relates to an acryloyl-containing compound as shown in a formula (1) and a preparation method thereof, and a
Selinexor
Riaz,Burke,Mahipal
, p. 685 - 692 (2015/02/02)
Advances in the understanding of the pathophysiology, molecular biology and genetics of solid tumors and hematological malignancies have culminated in the development of novel targeted therapeutic agents leading to improved prognosis and quality of life for cancer patients. Despite these advances, prognosis remains poor for many cancer patients, and there is an unmet need for new therapeutic options. Exportin-1 (XPO1) is a nuclear export receptor that is responsible for exporting proteins, including tumor suppressor proteins, out of the nucleus. Nuclear export of tumor suppressor proteins is an important mechanism by which cancer cells avoid apoptosis and cell death. Overexpression of XPO1 imparts poor prognosis, indicating that XPO1 inhibition can be a potential therapeutic target. Recently, selective inhibitors of nuclear export (SINE) drugs have been developed. Selinexor (KPT-330) is an oral SINE with a favorable toxicity profile and demonstrated to have preclinical and clinical activity against a broad range of solid tumors and hematological malignancies.
NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
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Paragraph 00261, (2013/12/03)
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.